TY - JOUR
T1 - Combination hepatic arterial infusion therapy is effective for ocular melanoma metastasis to the liver
AU - Ueda, Hiroki
AU - Hamagami, Hiroko
AU - Tanaka, Hiroto
AU - Kida, Yohei
AU - Ichinose, Masakazu
PY - 2005/12
Y1 - 2005/12
N2 - Regional treatments including chemotherapy have been applied to patients with malignant melanoma metastasis to the liver in clinical trials, but with limited efficacy. To improve efficacy, combination therapy may be beneficial. We had a case of multiple liver metastasis from right ocular malignant melanoma. The primary melanoma was surgically resected, and combination hepatic arterial infusion (HAI) therapy using dacarbazine, nimustine, vincristine (DAV), and cisplatin was applied to the metastatic focus. After HAI, marked regression of the liver metastatic focus was observed. Unfortunately, the patient passed away due to involvement of thrombotic thrombocytopenic purpura 9 months after the initial consultation, however, aggravation of the liver metastatic focus was not observed. Combination HAI therapy may have a potent therapeutic effect on malignant melanoma metastasis to the liver, and our regimen using DAV and CDDP may be beneficial to the improvement of prognosis without serious side effects.
AB - Regional treatments including chemotherapy have been applied to patients with malignant melanoma metastasis to the liver in clinical trials, but with limited efficacy. To improve efficacy, combination therapy may be beneficial. We had a case of multiple liver metastasis from right ocular malignant melanoma. The primary melanoma was surgically resected, and combination hepatic arterial infusion (HAI) therapy using dacarbazine, nimustine, vincristine (DAV), and cisplatin was applied to the metastatic focus. After HAI, marked regression of the liver metastatic focus was observed. Unfortunately, the patient passed away due to involvement of thrombotic thrombocytopenic purpura 9 months after the initial consultation, however, aggravation of the liver metastatic focus was not observed. Combination HAI therapy may have a potent therapeutic effect on malignant melanoma metastasis to the liver, and our regimen using DAV and CDDP may be beneficial to the improvement of prognosis without serious side effects.
KW - Combination hepatic arterial infusion
KW - Liver metastasis
KW - Ocular melanoma
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U2 - 10.3892/or.14.6.1543
DO - 10.3892/or.14.6.1543
M3 - Article
C2 - 16273253
AN - SCOPUS:33644696060
VL - 14
SP - 1543
EP - 1546
JO - Oncology Reports
JF - Oncology Reports
SN - 1021-335X
IS - 6
ER -