Combination chemotherapy with nedaplatin and 5-fluorouracil for oral squamous cell carcinomas

Kaoru Yamaoka, Masayuki Fukuda, Seiichi Kuwajima, Hisako Hagiwara, Shinichi Toshima, Atsushi Matsuoka, Takayoshi Ohnuki, Hiroshi Seki, Hirokazu Nagai, Mitsuyoshi Iino, Masato Sageshima

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

We used a new combination chemotherapy with nedaplatin (CDGP) and 5-fluorouracil (5-FU) in eleven fresh patients with oral squamous cell carcinomas. 5-FU was administered at a dose of 1,000 mg/body by continuous infusion for 24 hours on days 1 to 5. CDGP was administered at a dose of 80 or 100 mg/m2 by drip infusion for 120 minutes on day 5. The response rates of total (1- or 2-course) and 2-course group were 54. 5% and 83.3%, respectively. Adverse drug reactions were limited to two cases of grade 3 toxicity with anorexia. The combination chemotherapy with 5-FU and CDGP in place of cisplatin and 5-FU seemed to play an important role as neo-adjuvant chemotherapy for oral squamous cell carcinomas.

Original languageEnglish
Pages (from-to)951-955
Number of pages5
JournalGan to kagaku ryoho. Cancer & chemotherapy
Volume30
Issue number7
Publication statusPublished - 2003 Jul
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Combination chemotherapy with nedaplatin and 5-fluorouracil for oral squamous cell carcinomas'. Together they form a unique fingerprint.

Cite this