Combination chemotherapy with nedaplatin and 5-fluorouracil for oral squamous cell carcinomas

Kaoru Yamaoka; Masayuki Fukuda; Seiichi Kuwajima; Hisako Hagiwara; Shinichi Toshima; Atsushi Matsuoka; Takayoshi Ohnuki; Hiroshi Seki; Hirokazu Nagai; Mitsuyoshi Iino; Masato Sageshima

Combination chemotherapy with nedaplatin and 5-fluorouracil for oral squamous cell carcinomas

Kaoru Yamaoka, Masayuki Fukuda, Seiichi Kuwajima, Hisako Hagiwara, Shinichi Toshima, Atsushi Matsuoka, Takayoshi Ohnuki, Hiroshi Seki, Hirokazu Nagai, Mitsuyoshi Iino, Masato Sageshima

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

We used a new combination chemotherapy with nedaplatin (CDGP) and 5-fluorouracil (5-FU) in eleven fresh patients with oral squamous cell carcinomas. 5-FU was administered at a dose of 1,000 mg/body by continuous infusion for 24 hours on days 1 to 5. CDGP was administered at a dose of 80 or 100 mg/m2 by drip infusion for 120 minutes on day 5. The response rates of total (1- or 2-course) and 2-course group were 54. 5% and 83.3%, respectively. Adverse drug reactions were limited to two cases of grade 3 toxicity with anorexia. The combination chemotherapy with 5-FU and CDGP in place of cisplatin and 5-FU seemed to play an important role as neo-adjuvant chemotherapy for oral squamous cell carcinomas.

Original language	English
Pages (from-to)	951-955
Number of pages	5
Journal	Gan to kagaku ryoho. Cancer & chemotherapy
Volume	30
Issue number	7
Publication status	Published - 2003 Jul
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

Fingerprint Dive into the research topics of 'Combination chemotherapy with nedaplatin and 5-fluorouracil for oral squamous cell carcinomas'. Together they form a unique fingerprint.

Cite this

Combination chemotherapy with nedaplatin and 5-fluorouracil for oral squamous cell carcinomas. / Yamaoka, Kaoru; Fukuda, Masayuki; Kuwajima, Seiichi; Hagiwara, Hisako; Toshima, Shinichi; Matsuoka, Atsushi; Ohnuki, Takayoshi; Seki, Hiroshi; Nagai, Hirokazu; Iino, Mitsuyoshi; Sageshima, Masato.

In: Gan to kagaku ryoho. Cancer & chemotherapy, Vol. 30, No. 7, 07.2003, p. 951-955.

Research output: Contribution to journal › Article › peer-review

Yamaoka, Kaoru ; Fukuda, Masayuki ; Kuwajima, Seiichi ; Hagiwara, Hisako ; Toshima, Shinichi ; Matsuoka, Atsushi ; Ohnuki, Takayoshi ; Seki, Hiroshi ; Nagai, Hirokazu ; Iino, Mitsuyoshi ; Sageshima, Masato. / Combination chemotherapy with nedaplatin and 5-fluorouracil for oral squamous cell carcinomas. In: Gan to kagaku ryoho. Cancer & chemotherapy. 2003 ; Vol. 30, No. 7. pp. 951-955.

@article{ee13d33b19554ff1966b429a1b881676,

title = "Combination chemotherapy with nedaplatin and 5-fluorouracil for oral squamous cell carcinomas",

abstract = "We used a new combination chemotherapy with nedaplatin (CDGP) and 5-fluorouracil (5-FU) in eleven fresh patients with oral squamous cell carcinomas. 5-FU was administered at a dose of 1,000 mg/body by continuous infusion for 24 hours on days 1 to 5. CDGP was administered at a dose of 80 or 100 mg/m2 by drip infusion for 120 minutes on day 5. The response rates of total (1- or 2-course) and 2-course group were 54. 5% and 83.3%, respectively. Adverse drug reactions were limited to two cases of grade 3 toxicity with anorexia. The combination chemotherapy with 5-FU and CDGP in place of cisplatin and 5-FU seemed to play an important role as neo-adjuvant chemotherapy for oral squamous cell carcinomas.",

author = "Kaoru Yamaoka and Masayuki Fukuda and Seiichi Kuwajima and Hisako Hagiwara and Shinichi Toshima and Atsushi Matsuoka and Takayoshi Ohnuki and Hiroshi Seki and Hirokazu Nagai and Mitsuyoshi Iino and Masato Sageshima",

year = "2003",

month = jul,

language = "English",

volume = "30",

pages = "951--955",

journal = "Japanese Journal of Cancer and Chemotherapy",

issn = "0385-0684",

publisher = "Japanese Journal of Cancer and Chemotherapy Publishers Inc.",

number = "7",

}

TY - JOUR

T1 - Combination chemotherapy with nedaplatin and 5-fluorouracil for oral squamous cell carcinomas

AU - Yamaoka, Kaoru

AU - Fukuda, Masayuki

AU - Kuwajima, Seiichi

AU - Hagiwara, Hisako

AU - Toshima, Shinichi

AU - Matsuoka, Atsushi

AU - Ohnuki, Takayoshi

AU - Seki, Hiroshi

AU - Nagai, Hirokazu

AU - Iino, Mitsuyoshi

AU - Sageshima, Masato

PY - 2003/7

Y1 - 2003/7

N2 - We used a new combination chemotherapy with nedaplatin (CDGP) and 5-fluorouracil (5-FU) in eleven fresh patients with oral squamous cell carcinomas. 5-FU was administered at a dose of 1,000 mg/body by continuous infusion for 24 hours on days 1 to 5. CDGP was administered at a dose of 80 or 100 mg/m2 by drip infusion for 120 minutes on day 5. The response rates of total (1- or 2-course) and 2-course group were 54. 5% and 83.3%, respectively. Adverse drug reactions were limited to two cases of grade 3 toxicity with anorexia. The combination chemotherapy with 5-FU and CDGP in place of cisplatin and 5-FU seemed to play an important role as neo-adjuvant chemotherapy for oral squamous cell carcinomas.

AB - We used a new combination chemotherapy with nedaplatin (CDGP) and 5-fluorouracil (5-FU) in eleven fresh patients with oral squamous cell carcinomas. 5-FU was administered at a dose of 1,000 mg/body by continuous infusion for 24 hours on days 1 to 5. CDGP was administered at a dose of 80 or 100 mg/m2 by drip infusion for 120 minutes on day 5. The response rates of total (1- or 2-course) and 2-course group were 54. 5% and 83.3%, respectively. Adverse drug reactions were limited to two cases of grade 3 toxicity with anorexia. The combination chemotherapy with 5-FU and CDGP in place of cisplatin and 5-FU seemed to play an important role as neo-adjuvant chemotherapy for oral squamous cell carcinomas.

UR - http://www.scopus.com/inward/record.url?scp=0041744011&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0041744011&partnerID=8YFLogxK

M3 - Article

C2 - 12894709

AN - SCOPUS:0041744011

VL - 30

SP - 951

EP - 955

JO - Japanese Journal of Cancer and Chemotherapy

JF - Japanese Journal of Cancer and Chemotherapy

SN - 0385-0684

IS - 7

ER -