Colorectal distention induces hippocampal noradrenaline release in rats: An in vivo microdialysis study

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

We tested our hypothesis that noradrenaline is released in the hippocampus by colorectal distention of rats, and that it induces pain-related behavior. Noradrenaline levels with colorectal distention were significantly higher than those with restraint stress and free moving. Abdominal contractions were induced only by colorectal distention. Our results suggest that noradrenaline levels increase in the hippocampus under colorectal distention and this may relate to behavioral changes.

Original languageEnglish
Pages (from-to)146-149
Number of pages4
JournalBrain research
Volume947
Issue number1
DOIs
Publication statusPublished - 2002 Aug 23

Keywords

  • Brain-gut interaction
  • Emotion
  • Irritable bowel syndrome
  • Microdialysis
  • Stress
  • Visceral perception

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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