Colonic Motility, Autonomic Function, and Gastrointestinal Hormones under Psychological Stress on Irritable Bowel Syndrome

Shin Fukudo, Jinichi Suzuki

Research output: Contribution to journalArticlepeer-review

90 Citations (Scopus)

Abstract

Effects of an artificial mental stress on colonic motility, autonomic nervous system, and gastrointestinal hormones were examined in patients with irritable bowel syndrome (IBS). The subjects were 20 patients with typical IBS and 12 controls. A transducer was inserted to the sigmoid colon from the anus for measuring colonic intraluminal pressure, and mirror drawing test was loaded as psychological stress. At the same time, coefficient of variation of R-R interval on ECG (CV-RR) was measured and the levels of plasma catecholamines, gastrin, glucagon, and motilin were assessed. Colonic motility showed a significant increase in the IBS patients during the stress compared with that in controls (p<0.01). Motilin also increased significantly in the IBS patients after the stress (p <0.01). CV-RR and motilin revealed positive relationship with colonic motility alteration in the IBS patients although no significant change was detected in controls. These phenomena are thought to be due to autonomic nervous dysfunction and/or gastrointestinal hormonal derrangements induced by psychological stress. It is suggested that organ specificity of the alimentary tract for the stress exists in this disease.-irritable bowel syndrome; psychological stress; colonic motility; autonomic nervous system; gastrointestinal hormones.

Original languageEnglish
Pages (from-to)373-385
Number of pages13
Journalthe tohoku journal of experimental medicine
Volume151
Issue number4
DOIs
Publication statusPublished - 1987

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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