Collagenase Activity in Relation to Pathological State of Cholesteatoma

Michitaka Iwanaga, Etsuo Yamamoto, Manabu Fukumoto

Research output: Contribution to journalArticlepeer-review


Collagenase activities of the cholesteatoma epithelium, mastoid bone and skin from the bony external auditory meatus were investigated. The collagenase activity was measured directly in homogenates of tissues using the reconstituted radioactive collagen substrate. Twenty-one patients with cholesteatoma were ranked in order of loss of the superstructure of the stapes, existence of eroded bony wall of the Fallopian canal and perilymphatic fistula. The collagenase activity of the cholesteatoma epithelium was higher in the group with a high degree of bone destruction than in the group with a low degree of bone destruction. High collagenase activity may be a factor in the clinical aggressiveness of cholesteatoma.

Original languageEnglish
Pages (from-to)435-441
Number of pages7
JournalPractica Oto-Rhino-Laryngologica
Publication statusPublished - 1983
Externally publishedYes

ASJC Scopus subject areas

  • Otorhinolaryngology


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