Cognitive function in rats with alcohol ingestion

H. Sasaki; Y. Matsuzaki; T. Nakagawa; H. Arai; M. Yamama; K. Sekizawa; Y. Ikarashi; Y. Maruyama

doi:10.1016/0091-3057(95)00186-Z

Cognitive function in rats with alcohol ingestion

H. Sasaki, Y. Matsuzaki, T. Nakagawa, H. Arai, M. Yamama, K. Sekizawa, Y. Ikarashi, Y. Maruyama

Division of Brain Science

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

The effect of alcohol ingestion on learning disturbances was tested in rats. Rats were fed either an alcohol solution or a nonalcohol solution. The concentration of acetylcholine in the whole brain was significantly lower in rats fed with alcohol than rats fed without alcohol. Passive avoidance learning shows a lower tendency in rats with alcohol compared to rats without alcohol, but the alcohol and control groups did not differ in passive avoidance learning. We suggest that alcohol may disturb acetylcholine metabolism in the brain.

Original language	English
Pages (from-to)	845-848
Number of pages	4
Journal	Pharmacology, Biochemistry and Behavior
Volume	52
Issue number	4
DOIs	https://doi.org/10.1016/0091-3057(95)00186-Z
Publication status	Published - 1995 Dec

Keywords

Acetylcholine
Alcohol
Cognitive function
Passive avoidance learning
Rats

ASJC Scopus subject areas

Biochemistry
Toxicology
Pharmacology
Clinical Biochemistry
Biological Psychiatry
Behavioral Neuroscience

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10.1016/0091-3057(95)00186-Z

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AU - Sasaki, H.

AU - Matsuzaki, Y.

AU - Nakagawa, T.

AU - Arai, H.

AU - Yamama, M.

AU - Sekizawa, K.

AU - Ikarashi, Y.

AU - Maruyama, Y.

PY - 1995/12

Y1 - 1995/12

N2 - The effect of alcohol ingestion on learning disturbances was tested in rats. Rats were fed either an alcohol solution or a nonalcohol solution. The concentration of acetylcholine in the whole brain was significantly lower in rats fed with alcohol than rats fed without alcohol. Passive avoidance learning shows a lower tendency in rats with alcohol compared to rats without alcohol, but the alcohol and control groups did not differ in passive avoidance learning. We suggest that alcohol may disturb acetylcholine metabolism in the brain.

AB - The effect of alcohol ingestion on learning disturbances was tested in rats. Rats were fed either an alcohol solution or a nonalcohol solution. The concentration of acetylcholine in the whole brain was significantly lower in rats fed with alcohol than rats fed without alcohol. Passive avoidance learning shows a lower tendency in rats with alcohol compared to rats without alcohol, but the alcohol and control groups did not differ in passive avoidance learning. We suggest that alcohol may disturb acetylcholine metabolism in the brain.

KW - Acetylcholine

KW - Alcohol

KW - Cognitive function

KW - Passive avoidance learning

KW - Rats

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Cognitive function in rats with alcohol ingestion

Abstract

Keywords

ASJC Scopus subject areas

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