Cognitive Function and Calcium. Cerebral calcium oscillation: functional implication toward cognitive functions

Makoto Osanai

Research output: Contribution to journalReview articlepeer-review

Abstract

Calcium is universal and versatile signal transduction molecule. Intracellular calcium is precisely regulated by various cellular mechanisms, making it possible to contribute to normal neuronal functions. Recently, the relationship between calcium and neuronal functions including cognitive functions has been investigated. This paper reviews normal and abnormal functions of calcium in a perspective of raveling the pathophysiology of neuropsychiatric disorders, such as Alzheimer's disease and Parkinson's disease. And, I introduce the slow calcium oscillation in striatum, which lasted more than 100 s, and discuss the pathophysiological function of the slow calcium oscillation in the neuropsychiatric disorder, especially in Parkinson's disease.

Original languageEnglish
Pages (from-to)217-225
Number of pages9
JournalClinical calcium
Volume25
Issue number2
Publication statusPublished - 2015 Feb 1

ASJC Scopus subject areas

  • Medicine(all)

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