Coffee consumption and the risk of primary liver cancer: Pooled analysis of two prospective studies in Japan

Taichi Shimazu, Yoshitaka Tsubono, Shinichi Kuriyama, Kaori Ohmori, Yayoi Koizumi, Yoshikazu Nishino, Daisuke Shibuya, Ichiro Tsuji

Research output: Contribution to journalArticlepeer-review

114 Citations (Scopus)

Abstract

Although case-control studies suggested that coffee consumption is associated with a decreased risk of liver cancer, no prospective cohort study has been carried out. To examine the association between coffee consumption and the risk of liver cancer, we conducted a pooled analysis of data available from 2 cohort studies in Japan. A self-administered questionnaire about the frequency of coffee consumption and other health habits was distributed to 22,404 subjects (10,588 men and 11,816 women) in Cohort 1 and 38,703 subjects (18,869 men and 19,834 women) in Cohort 2, aged 40 years or more, with no previous history of cancer. We identified 70 and 47 cases of liver cancer among the subjects in Cohort 1 (9 years of follow-up with 170,640 person-years) and Cohort 2 (7 years of follow-up with 284,948 person-years), respectively. We used Cox proportional hazards regression analysis to estimate the relative risk (RR) and 95% confidence interval (CI) of liver cancer incidence. After adjustment for potential confounders, the pooled RR (93% CI) of drinking coffee never, occasionally and 1 or more cups/day were 1.00 (Reference), 0.71 (0.46-1.09) and 0.58 (0.36-0.96), respectively (p for trend = 0.024). In the subgroup of subjects with a history of liver disease, we found a significant inverse association between coffee consumption and the risk of liver cancer. Our findings support the hypothesis that coffee consumption decreases the risk of liver cancer. Further studies to investigate the role of coffee in prevention of liver cancer among the high-risk population are needed.

Original languageEnglish
Pages (from-to)150-154
Number of pages5
JournalInternational Journal of Cancer
Volume116
Issue number1
DOIs
Publication statusPublished - 2005 Aug 10

Keywords

  • Coffee
  • Incidence
  • Japan
  • Liver neoplasms
  • Prospective studies

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Coffee consumption and the risk of primary liver cancer: Pooled analysis of two prospective studies in Japan'. Together they form a unique fingerprint.

Cite this