TY - JOUR
T1 - Coffee consumption and mortality in Japanese men and women
T2 - A pooled analysis of eight population-based cohort studies in Japan (Japan Cohort Consortium)
AU - for the Research Group for the Development and Evaluation of Cancer Prevention Strategies in Japan
AU - Abe, Sarah Krull
AU - Saito, Eiko
AU - Sawada, Norie
AU - Tsugane, Shoichiro
AU - Ito, Hidemi
AU - Lin, Yingsong
AU - Tamakoshi, Akiko
AU - Sado, Junya
AU - Kitamura, Yuri
AU - Tsuji, Ichiro
AU - Nagata, Chisato
AU - Sadakane, Atsuko
AU - Shimazu, Taichi
AU - Mizoue, Tetsuya
AU - Matsuo, Keitaro
AU - Naito, Mariko
AU - Tanaka, Keitaro
AU - Inoue, Manami
N1 - Funding Information:
This work was supported by the National Cancer Center Research and Development Funds [ 30-A-15 , 27-A-4 , 24-A-3 ] and the Health and Labour Sciences Research Grants for the Third Term Comprehensive Control Research for Cancer [ H21-3jigan-ippan-003 , H18-3jigan-ippan-001 , H16-3jigan-010 ]. The funders had no role in the design, data collection, analysis, interpretation or manuscript drafting, or in the decision to submit the manuscript for publication.
Publisher Copyright:
© 2019 Elsevier Inc.
PY - 2019/6
Y1 - 2019/6
N2 - Coffee consumption is increasing globally. We aimed to assess the effect of coffee consumption on the risk of all-cause and cause-specific mortality in a pooled analysis of eight population-based cohort studies in Japan (Japan Cohort Consortium). Data came from eight Japanese cohort studies (144,750 men and 168,631 women). During a mean follow-up time of 17 years, 52,943 deaths occurred. More specifically, 19,495 cancer deaths, 7321 deaths due to heart disease, 6387 cerebrovascular, 3490 respiratory disease and 3382 injuries and accidents. A random effects model was applied to obtain pooled hazard ratios (HRs) and 95% confidence intervals (95%CIs). In both sexes, coffee consumption up to 5 cups/day was overall protective in relation to all-cause mortality, with the association attenuating in the highest category of coffee consumption (≥5 cups/day). In men, a similar inverse association was observed for major causes of mortality except cancer. In women, coffee consumption decreased the risk for mortality due to heart disease in the 1–2 cups/day category, but increased the risk in the ≥5 cups/day category. Coffee consumption was not associated with cancer in both sexes. Results were similar among male current smokers and female never-smokers. Based on available data, this pooled analysis suggests that coffee consumption under five cups per day may be beneficial for reducing the risk of mortality due to major causes.
AB - Coffee consumption is increasing globally. We aimed to assess the effect of coffee consumption on the risk of all-cause and cause-specific mortality in a pooled analysis of eight population-based cohort studies in Japan (Japan Cohort Consortium). Data came from eight Japanese cohort studies (144,750 men and 168,631 women). During a mean follow-up time of 17 years, 52,943 deaths occurred. More specifically, 19,495 cancer deaths, 7321 deaths due to heart disease, 6387 cerebrovascular, 3490 respiratory disease and 3382 injuries and accidents. A random effects model was applied to obtain pooled hazard ratios (HRs) and 95% confidence intervals (95%CIs). In both sexes, coffee consumption up to 5 cups/day was overall protective in relation to all-cause mortality, with the association attenuating in the highest category of coffee consumption (≥5 cups/day). In men, a similar inverse association was observed for major causes of mortality except cancer. In women, coffee consumption decreased the risk for mortality due to heart disease in the 1–2 cups/day category, but increased the risk in the ≥5 cups/day category. Coffee consumption was not associated with cancer in both sexes. Results were similar among male current smokers and female never-smokers. Based on available data, this pooled analysis suggests that coffee consumption under five cups per day may be beneficial for reducing the risk of mortality due to major causes.
KW - Coffee
KW - Cohort study
KW - Japan
KW - Mortality
KW - Pooled analysis
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U2 - 10.1016/j.ypmed.2019.04.002
DO - 10.1016/j.ypmed.2019.04.002
M3 - Article
C2 - 30951734
AN - SCOPUS:85063955783
VL - 123
SP - 270
EP - 277
JO - Preventive Medicine
JF - Preventive Medicine
SN - 0091-7435
ER -