TY - JOUR
T1 - Coffee consumption and all-cause and cardiovascular mortality
T2 - - Three-prefecture cohort in Japan
AU - Sado, Junya
AU - Kitamura, Tetsuhisa
AU - Kitamura, Yuri
AU - Liu, Rong
AU - Ando, Emiko
AU - Sobue, Tomotaka
AU - Sugawara, Yumi
AU - Matsuo, Keitaro
AU - Nakayama, Tomio
AU - Tsuji, Ichiro
AU - Ito, Hidemi
AU - Suzuki, Takaichiro
AU - Katanoda, Kota
AU - Tominaga, Suketami
N1 - Funding Information:
We sincerely thank the staff in each study area for data collection and processing. We also express our gratitude to all the participants in the study. This study was supported by a Grant-in-Aid for Scientific Research (25460752) from the Ministry of Education, Culture, Sports, Science, and Technology of Japan. In addition, the Clinical Investigator’s Research Project in Osaka University Graduate School of Medicine supported this article.
Publisher Copyright:
© 2019, Japanese Circulation Society. All rights reserved.
PY - 2019/4
Y1 - 2019/4
N2 - Background: Coffee, which contains various bioactive compounds, is one of the most popular beverages. Further accumulation of evidence is needed, however, to confirm whether coffee consumption would be effective in preventing cardiovascular disease in the general Japanese population. Methods and Results: We evaluated the association between coffee consumption frequency (never, sometimes, 1-2 cups/day, 3-4 cups/day and =5 cups/day) and mortality from all causes, heart disease, and cerebrovascular disease, in 39,685 men and 43,124 women aged 40-79 years at baseline, in a 3-prefecture cohort study. The coffee consumption frequency was assessed on questionnaire. Cox proportional hazards regression modeling was used to assess the association between coffee consumption frequency and all-cause and cardiovascular disease mortality with adjustment for potential confounders. During 411,341 and 472,433 person-years in men and women, respectively, a total of 7,955 men and 5,725 women died. Coffee consumption frequency was inversely associated with all-cause mortality in both genders (P for trend<0.001). In addition, the risks of mortality from cerebrovascular disease in men (P for trend<0.001), and heart disease in women (P for trend=0.031) were inversely associated with coffee consumption. Conclusions: In this Japanese population, coffee drinking has a preventive effect on all-cause and on cardiovascular mortality in men and/or women.
AB - Background: Coffee, which contains various bioactive compounds, is one of the most popular beverages. Further accumulation of evidence is needed, however, to confirm whether coffee consumption would be effective in preventing cardiovascular disease in the general Japanese population. Methods and Results: We evaluated the association between coffee consumption frequency (never, sometimes, 1-2 cups/day, 3-4 cups/day and =5 cups/day) and mortality from all causes, heart disease, and cerebrovascular disease, in 39,685 men and 43,124 women aged 40-79 years at baseline, in a 3-prefecture cohort study. The coffee consumption frequency was assessed on questionnaire. Cox proportional hazards regression modeling was used to assess the association between coffee consumption frequency and all-cause and cardiovascular disease mortality with adjustment for potential confounders. During 411,341 and 472,433 person-years in men and women, respectively, a total of 7,955 men and 5,725 women died. Coffee consumption frequency was inversely associated with all-cause mortality in both genders (P for trend<0.001). In addition, the risks of mortality from cerebrovascular disease in men (P for trend<0.001), and heart disease in women (P for trend=0.031) were inversely associated with coffee consumption. Conclusions: In this Japanese population, coffee drinking has a preventive effect on all-cause and on cardiovascular mortality in men and/or women.
KW - Cardiovascular disease
KW - Coffee consumption
KW - Cohort
KW - Japanese
KW - Mortality
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U2 - 10.1253/circj.CJ-18-0618
DO - 10.1253/circj.CJ-18-0618
M3 - Article
C2 - 30853684
AN - SCOPUS:85063712097
VL - 83
SP - 757
EP - 766
JO - Circulation Journal
JF - Circulation Journal
SN - 1346-9843
IS - 4
ER -