Coexistence of calcium-binding proteins in vagal and glossopharyngeal sensory neurons of the rat

Hiroyuki Ichikawa, Cinda J. Helke

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The presence and coexistence of the calcium-binding proteins (CaBPs), calbindin D-28k, parvalbumin and S100 protein, were immunohistochemically examined in the glossopharyngeal and vagal sensory ganglia, the carotid body and taste buds. The CaBPs were found in each ganglion with the nodose ganglion containing the largest number of CaBP-immunoreactive (ir) cells (calbindin D-28k ≤ S100 >> parvalbumin). The coexistence of CaBPs was found in neurons of the nodose, petrosal, and jugular ganglia. Calbindin D-28k-ir neurons in the nodose and petrosal ganglia frequently colocalized S100-ir whereas calbindin D-28k-ir neurons in the jugular ganglion less frequently contained S100-ir. Only small percentages of calbindin D-28k-ir neurons in each ganglion colocalized parvalbumin. Similarly, S100-ir neurons in the nodose and petrosal ganglia frequently colocalized calbindin D-28k-ir whereas S100-ir neurons in the jugular ganglion less frequently contained calbindin D-28k-ir. Moderate to small percentages of S100-ir neurons in each ganglion colocalized parvalbumin. Parvalbumin-ir neurons nearly always colocalized S100-ir in the nodose, petrosal and jugular ganglia. Moderate to small percentages of parvalbumin-ir neurons in each ganglion colocalized calbindin D-28k. Whereas calbindin D-28k- and S100-ir were colocalized in nerve fibers and cells within taste buds of circumvallate papilla of the tongue, the coexistence of these CaBPs could not be determined in the carotid body. These findings suggest a cooperative role for CaBPs in the functions of subpopulations of nodose and petrosal ganglia neurons.

Original languageEnglish
Pages (from-to)349-353
Number of pages5
JournalBrain research
Volume768
Issue number1-2
DOIs
Publication statusPublished - 1997 Sep 12
Externally publishedYes

Keywords

  • Calbindin D-28k
  • Immunohistochemistry
  • Jugular ganglion
  • Nodose ganglion
  • Parvalbumin
  • Petrosal ganglion
  • S100
  • Vagal afferent neuron

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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