Codon 219 Lys allele of PRNP is not found in sporadic Creutzfeldt-Jakob disease

Satoshi Shibuya, Jun Higuchi, Ryong Woon Shin, Jun Tateishi, Tetsuyuki Kitamoto

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144 Citations (Scopus)

Abstract

The polymorphism at codon 219 of the prion protein gene (PRNP) was found in the general Japanese population with 6% allele frequency. Herein, we examined 85 cases of sporadic Creutzfeldt-Jakob disease (CJD) for the codon 219 polymorphism. The codon 219(Glu/Lys) heterozygous polymorphism was not found in these CJD cases. In addition, we examined 43 patients with dementia of non-CJD origin, and 4 were found to have the codon 219(Glu/Lys) heterozygous polymorphism with a similar allele frequency as in the general population. Thus, the codon 219(Glu/Lys) heterozygous polymorphism might be uniquely excluded from sporadic CJD.

Original languageEnglish
Pages (from-to)826-828
Number of pages3
JournalAnnals of Neurology
Volume43
Issue number6
DOIs
Publication statusPublished - 1998 Jun

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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