Cobalt-catalyzed ortho-C-H alkylation of 2-arylpyridines via ring-opening of aziridines

Ke Gao; Rupankar Paira; Naohiko Yoshikai

doi:10.1002/adsc.201400049

Cobalt-catalyzed ortho-C-H alkylation of 2-arylpyridines via ring-opening of aziridines

Ke Gao, Rupankar Paira, Naohiko Yoshikai

Research output: Contribution to journal › Article › peer-review

57 Citations (Scopus)

Abstract

A cobalt-N-heterocyclic carbene catalyst, in combination with neopentylmagnesium bromide, was found to promote ortho-C-H functionalization of 2-arylpyridines with 1,2-diarylaziridines through ring-opening alkylation. The reaction affords 1,1-diarylethanes bearing 2-amino functional groups in moderate to good yields under mild room-temperature conditions.

Original language	English
Pages (from-to)	1486-1490
Number of pages	5
Journal	Advanced Synthesis and Catalysis
Volume	356
Issue number	7
DOIs	https://doi.org/10.1002/adsc.201400049
Publication status	Published - 2014 May 5
Externally published	Yes

Keywords

aziridines
C-C bond formation
C-H functionalization
cobalt

ASJC Scopus subject areas

Catalysis
Organic Chemistry

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abstract = "A cobalt-N-heterocyclic carbene catalyst, in combination with neopentylmagnesium bromide, was found to promote ortho-C-H functionalization of 2-arylpyridines with 1,2-diarylaziridines through ring-opening alkylation. The reaction affords 1,1-diarylethanes bearing 2-amino functional groups in moderate to good yields under mild room-temperature conditions.",

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AU - Paira, Rupankar

AU - Yoshikai, Naohiko

PY - 2014/5/5

Y1 - 2014/5/5

N2 - A cobalt-N-heterocyclic carbene catalyst, in combination with neopentylmagnesium bromide, was found to promote ortho-C-H functionalization of 2-arylpyridines with 1,2-diarylaziridines through ring-opening alkylation. The reaction affords 1,1-diarylethanes bearing 2-amino functional groups in moderate to good yields under mild room-temperature conditions.

AB - A cobalt-N-heterocyclic carbene catalyst, in combination with neopentylmagnesium bromide, was found to promote ortho-C-H functionalization of 2-arylpyridines with 1,2-diarylaziridines through ring-opening alkylation. The reaction affords 1,1-diarylethanes bearing 2-amino functional groups in moderate to good yields under mild room-temperature conditions.

KW - aziridines

KW - C-C bond formation

KW - C-H functionalization

KW - cobalt

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Cobalt-catalyzed ortho-C-H alkylation of 2-arylpyridines via ring-opening of aziridines

Abstract

Keywords

ASJC Scopus subject areas

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