Cobalt-catalyzed ortho -arylation of aromatic imines with aryl chlorides

Ke Gao, Pin Sheng Lee, Chong Long, Naohiko Yoshikai

Research output: Contribution to journalArticlepeer-review

74 Citations (Scopus)

Abstract

An ortho-arylation reaction of aromatic imines with aryl chlorides has been achieved using a cobalt-N-heterocyclic carbene catalyst in combination with a neopentyl Grignard reagent. The reaction takes place at room temperature to afford biaryl products in moderate to good yields.

Original languageEnglish
Pages (from-to)4234-4237
Number of pages4
JournalOrganic letters
Volume14
Issue number16
DOIs
Publication statusPublished - 2012 Aug 17
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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