Cobalt-Catalyzed, N-H Imine-Directed Hydroarylation of Styrenes

Wengang Xu, Naohiko Yoshikai

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

A cobalt-catalyzed, N-H imine-directed hydroarylation reaction of styrenes is reported. A variety of diaryl and aryl alkyl N-H imines participated in the reaction to afford the corresponding branched adducts in good yield and regioselectivity. Interestingly, unsymmetrical diaryl imines with modest electronic biases reacted regioselectively at one of the aryl rings. Furthermore, the branched selectivity was reversed for substrates bearing a secondary directing group or a bulky pivaloyl N-H imine.

Original languageEnglish
Pages (from-to)1392-1395
Number of pages4
JournalOrganic letters
Volume20
Issue number5
DOIs
Publication statusPublished - 2018 Mar 2
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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