TY - JOUR
T1 - Cobalt-Catalyzed, N-H Imine-Directed Arene C-H Benzylation with Benzyl Phosphates
AU - Laskar, Roshayed Ali
AU - Yoshikai, Naohiko
N1 - Funding Information:
This work was supported by Nanyang Technological University and the Singapore Ministry of Education (MOE2016-T2-2-043).
Publisher Copyright:
© 2019 American Chemical Society.
PY - 2019/10/18
Y1 - 2019/10/18
N2 - A cobalt-catalyzed ortho-C-H benzylation reaction of pivalophenone N-H imines with benzyl phosphates is reported. The reaction is promoted at room temperature by a ternary catalytic system comprising Co(acac)3, a pyridylphosphine ligand, and a Grignard reagent and tolerates a series of substituted pivalophenone imines and benzyl phosphates to afford various diarylmethane derivatives in moderate yields.
AB - A cobalt-catalyzed ortho-C-H benzylation reaction of pivalophenone N-H imines with benzyl phosphates is reported. The reaction is promoted at room temperature by a ternary catalytic system comprising Co(acac)3, a pyridylphosphine ligand, and a Grignard reagent and tolerates a series of substituted pivalophenone imines and benzyl phosphates to afford various diarylmethane derivatives in moderate yields.
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U2 - 10.1021/acs.joc.9b01775
DO - 10.1021/acs.joc.9b01775
M3 - Article
C2 - 31389240
AN - SCOPUS:85071871010
VL - 84
SP - 13172
EP - 13178
JO - Journal of Organic Chemistry
JF - Journal of Organic Chemistry
SN - 0022-3263
IS - 20
ER -