Cobalt-Catalyzed, N-H Imine-Directed Arene C-H Benzylation with Benzyl Phosphates

Roshayed Ali Laskar; Naohiko Yoshikai

doi:10.1021/acs.joc.9b01775

Cobalt-Catalyzed, N-H Imine-Directed Arene C-H Benzylation with Benzyl Phosphates

Roshayed Ali Laskar, Naohiko Yoshikai

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

A cobalt-catalyzed ortho-C-H benzylation reaction of pivalophenone N-H imines with benzyl phosphates is reported. The reaction is promoted at room temperature by a ternary catalytic system comprising Co(acac)₃, a pyridylphosphine ligand, and a Grignard reagent and tolerates a series of substituted pivalophenone imines and benzyl phosphates to afford various diarylmethane derivatives in moderate yields.

Original language	English
Pages (from-to)	13172-13178
Number of pages	7
Journal	Journal of Organic Chemistry
Volume	84
Issue number	20
DOIs	https://doi.org/10.1021/acs.joc.9b01775
Publication status	Published - 2019 Oct 18
Externally published	Yes

ASJC Scopus subject areas

Organic Chemistry

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title = "Cobalt-Catalyzed, N-H Imine-Directed Arene C-H Benzylation with Benzyl Phosphates",

abstract = "A cobalt-catalyzed ortho-C-H benzylation reaction of pivalophenone N-H imines with benzyl phosphates is reported. The reaction is promoted at room temperature by a ternary catalytic system comprising Co(acac)3, a pyridylphosphine ligand, and a Grignard reagent and tolerates a series of substituted pivalophenone imines and benzyl phosphates to afford various diarylmethane derivatives in moderate yields.",

author = "Laskar, {Roshayed Ali} and Naohiko Yoshikai",

note = "Funding Information: This work was supported by Nanyang Technological University and the Singapore Ministry of Education (MOE2016-T2-2-043). Publisher Copyright: {\textcopyright} 2019 American Chemical Society.",

year = "2019",

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day = "18",

doi = "10.1021/acs.joc.9b01775",

language = "English",

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journal = "Journal of Organic Chemistry",

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AU - Laskar, Roshayed Ali

AU - Yoshikai, Naohiko

PY - 2019/10/18

Y1 - 2019/10/18

N2 - A cobalt-catalyzed ortho-C-H benzylation reaction of pivalophenone N-H imines with benzyl phosphates is reported. The reaction is promoted at room temperature by a ternary catalytic system comprising Co(acac)3, a pyridylphosphine ligand, and a Grignard reagent and tolerates a series of substituted pivalophenone imines and benzyl phosphates to afford various diarylmethane derivatives in moderate yields.

AB - A cobalt-catalyzed ortho-C-H benzylation reaction of pivalophenone N-H imines with benzyl phosphates is reported. The reaction is promoted at room temperature by a ternary catalytic system comprising Co(acac)3, a pyridylphosphine ligand, and a Grignard reagent and tolerates a series of substituted pivalophenone imines and benzyl phosphates to afford various diarylmethane derivatives in moderate yields.

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JF - Journal of Organic Chemistry

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Cobalt-Catalyzed, N-H Imine-Directed Arene C-H Benzylation with Benzyl Phosphates

Abstract

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