Cobalt-catalyzed intramolecular olefin hydroarylation leading to dihydropyrroloindoles and tetrahydropyridoindoles

Zhenhua Ding, Naohiko Yoshikai

Research output: Contribution to journalArticlepeer-review

95 Citations (Scopus)

Abstract

Regiodivergent catalysis: Cobalt N-heterocyclic carbene (NHC) catalysts promote intramolecular olefin hydroarylation of indoles bearing an N-homoallyl or bis(homoallyl) tether and a C3 aldimine directing group to afford dihydropyrroloindoles and tetrahydropyridoindoles under mild conditions. The course of the cyclization is dependent on the tether, but can be controlled by the NHC ligand.

Original languageEnglish
Pages (from-to)8574-8578
Number of pages5
JournalAngewandte Chemie - International Edition
Volume52
Issue number33
DOIs
Publication statusPublished - 2013 Aug 12
Externally publishedYes

Keywords

  • C-H activation
  • alkenes
  • cobalt
  • indoles
  • intramolecular reactions

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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