Cobalt-Catalyzed, Imine-Directed Olefin Hydroarylation under Grignard-Free Conditions

Wengang Xu, Jie Hui Pek, Naohiko Yoshikai

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

We report here that a cobalt catalyst generated from a cobalt(II) salt and a ligand using magnesium metal is capable of promoting hydroarylation reactions through chelation-assisted C−H activation. With the appropriate choice of the ligand and other reaction conditions, ketimine- or aldimine-directed branched selective hydroarylations of styrenes and ketimine-directed hydroarylations of vinylsilane have been achieved. The reported catalytic systems may serve as more convenient alternatives to previously developed catalytic systems employing Grignard reagents as reducing agents. (Figure presented.).

Original languageEnglish
Pages (from-to)2564-2568
Number of pages5
JournalAdvanced Synthesis and Catalysis
Volume358
Issue number15
DOIs
Publication statusPublished - 2016 Jul 28
Externally publishedYes

Keywords

  • alkenes
  • cobalt
  • C−C bond formation
  • C−H activation
  • hydroarylation

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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