Cobalt-catalyzed hydroarylation of alkynes through chelation-assisted C-H bond activation

Ke Gao, Pin Sheng Lee, Takeshi Fujita, Naohiko Yoshikai

Research output: Contribution to journalArticlepeer-review

222 Citations (Scopus)

Abstract

Ternary catalytic systems consisting of cobalt salts, phosphine ligands, and Grignard reagents promote addition of arylpyridines and imines to unactivated internal alkynes with high regio- and stereoselectivities. Deuterium-labeling experiments suggest that the reaction involves chelation-assisted oxidative addition of the aryl C-H bond to the cobalt center and insertion of the C-C triple bond into the Co-H bond, followed by reductive elimination of the resulting diorganocobalt species.

Original languageEnglish
Pages (from-to)12249-12251
Number of pages3
JournalJournal of the American Chemical Society
Volume132
Issue number35
DOIs
Publication statusPublished - 2010 Sep 8
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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