Cobalt-catalyzed directed alkylation of olefinic C-H bond with primary and secondary alkyl chlorides

Takeshi Yamakawa, Yuan Wah Seto, Naohiko Yoshikai

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

A cobalt-N-heterocyclic carbene catalytic system promotes pyridine-directed olefinic C-H alkylation reactions using a variety of primary and secondary alkyl chlorides under mild conditions. Radical clock experiments suggest that the reaction involves single-electron transfer from the cobalt intermediate to the alkyl chloride.

Original languageEnglish
Pages (from-to)340-344
Number of pages5
JournalSynlett
Volume26
Issue number3
DOIs
Publication statusPublished - 2015 Feb
Externally publishedYes

Keywords

  • alkenes
  • alkyl halides
  • alkylations
  • C-H activation
  • cobalt

ASJC Scopus subject areas

  • Organic Chemistry

Fingerprint

Dive into the research topics of 'Cobalt-catalyzed directed alkylation of olefinic C-H bond with primary and secondary alkyl chlorides'. Together they form a unique fingerprint.

Cite this