Cobalt-Catalyzed Alkenylzincation of Unfunctionalized Alkynes

Junliang Wu, Naohiko Yoshikai

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)

Abstract

While transition metal catalyzed addition reactions of arylmetal reagents to unfunctionalized alkynes have been extensively developed in the last decade, analogous reactions using alkenylmetal reagents remain rare regardless of their potential utility for the synthesis of unsymmetrical 1,3-dienes. Reported herein is the development of a cobalt/diphosphine catalyst which promotes efficient and stereoselective addition of alkenylzinc reagents to unfunctionalized internal alkynes. The resulting dienylzinc species serve as versatile intermediates for further synthetic transformations.

Original languageEnglish
Pages (from-to)336-340
Number of pages5
JournalAngewandte Chemie - International Edition
Volume55
Issue number1
DOIs
Publication statusPublished - 2016 Jan 4
Externally publishedYes

Keywords

  • alkenes
  • alkynes
  • cobalt
  • homogeneous catalysis
  • organometallic reagents

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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