Cobalt-catalyzed addition of arylzinc reagents to norbornene derivatives through 1,4-cobalt migration

Boon Hong Tan, Naohiko Yoshikai

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

A cobalt-diphosphine catalyst promotes the addition of an arylzinc reagent to a norbornene derivative to afford o-(2-exo-norbornyl)arylzinc species. This "migratory arylzincation" reaction is considered to involve insertion of norbornene into an arylcobalt species, alkyl-to-aryl 1,4-cobalt migration, and transmetalation between the resulting o-(2-exo-norbornyl)arylcobalt species and the arylzinc reagent. The o-(2-exo-norbornyl)arylzinc species can be intercepted by common organic electrophiles under copper or palladium catalysis.

Original languageEnglish
Pages (from-to)3392-3395
Number of pages4
JournalOrganic letters
Volume16
Issue number12
DOIs
Publication statusPublished - 2014 Jun 20
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Fingerprint

Dive into the research topics of 'Cobalt-catalyzed addition of arylzinc reagents to norbornene derivatives through 1,4-cobalt migration'. Together they form a unique fingerprint.

Cite this