Co-occurrence of hypertrophic cardiomyopathy and juvenile myelomonocytic leukemia in a neonate with Noonan syndrome, leading to premature death

Akihiro Tamura, Suguru Uemura, Kousaku Matsubara, Eru Kozuki, Toshikatsu Tanaka, Nanako Nino, Takehito Yokoi, Atsuro Saito, Toshiaki Ishida, Daiichiro Hasegawa, Ikumi Umeki, Tetsuya Niihori, Yozo Nakazawa, Kenichi Koike, Yoko Aoki, Yoshiyuki Kosaka

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Abstract

We report a case of a neonate with Noonan syndrome presenting with concurrent hypertrophic cardiomyopathy and juvenile myelomonocytic leukemia, which resulted in premature death. Cases with Noonan syndrome diagnosed during the neonatal period might not necessarily show mild clinical course, and premature death is a possible outcome to be considered.

Original languageEnglish
Pages (from-to)1202-1207
Number of pages6
JournalClinical Case Reports
Volume6
Issue number7
DOIs
Publication statusPublished - 2018 Jul

Keywords

  • Noonan syndrome
  • hypertrophic cardiomyopathy
  • juvenile myelomonocytic leukemia
  • p.Thr42Ala
  • premature death

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Tamura, A., Uemura, S., Matsubara, K., Kozuki, E., Tanaka, T., Nino, N., Yokoi, T., Saito, A., Ishida, T., Hasegawa, D., Umeki, I., Niihori, T., Nakazawa, Y., Koike, K., Aoki, Y., & Kosaka, Y. (2018). Co-occurrence of hypertrophic cardiomyopathy and juvenile myelomonocytic leukemia in a neonate with Noonan syndrome, leading to premature death. Clinical Case Reports, 6(7), 1202-1207. https://doi.org/10.1002/ccr3.1568