Co-expression of VRL-1 and calbindin D-28k in the rat sensory ganglia

H. Ichikawa, T. Sugimoto

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

The co-expression of vanilloid receptor 1-like receptor (VRL-1), a newly cloned capsaicin-receptor homologue, with calbindin D-28k was examined in the rat sensory ganglia. The co-expression was rare in the dorsal root, trigeminal and jugular ganglia and abundant in the petrosal and nodose ganglia. In the dorsal root ganglion, none of VRL-1-immunoreactive (ir) neuron co-expressed calbindin D-28k-immunoreactivity (ir). Of the VRL-1-ir neurons, 9 and 5% showed calbindin D-28k ir in the trigeminal and jugular ganglia, respectively. On the other hand, 35 and 63% of VRL-1-ir neurons in the petrosal and nodose ganglia, respectively, co-expressed these substances. The retrograde tracing method indicated that petrosal neurons which co-expressed VRL-1-and calbindin D-28k-ir innervated taste buds in the circumvallate papilla. The present findings may suggest that VRL-1 is associated with chemosensory functions in visceral sensory neurons.

Original languageEnglish
Pages (from-to)109-112
Number of pages4
JournalBrain research
Volume924
Issue number1
DOIs
Publication statusPublished - 2002 Jan 4
Externally publishedYes

Keywords

  • Calbindin D-28k
  • Immunohistochemistry
  • Petrosal ganglion
  • Taste bud
  • VRL-1

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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