Abstract
Pouchitis-the most common complication of total proctocolectomy and anal ileal-pouch anastomosis for ulcerative colitis-is effectively treated in most patients by antibiotic ciprofloxacin or metronidazole therapy, In some cases, however, pouchitis is refractory to these antibiotics. We detected Clostridium difficile toxin A in the feces of three patients suffering from antibiotic-refractory pouchitis whose mucosal inflammation was ameliorated by oral vancomycin treatment. C. difficile should therefore be considered in antibiotic-refractory pouchitis, which requires appropriate medication.
Original language | English |
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Pages (from-to) | 270-276 |
Number of pages | 7 |
Journal | Japanese Journal of Gastroenterological Surgery |
Volume | 43 |
Issue number | 3 |
DOIs | |
Publication status | Published - 2010 Mar |
Keywords
- C. Difficile
- Pouchitis
ASJC Scopus subject areas
- Surgery
- Gastroenterology