Clostridium difficile-associated refractory pouchitis: Report of three cases

Hitoshi Ogawa; Kouhei Fukushima; Chikashi Shibata; Koh Miura; Sho Haneda; Keiichi Hayashi; Hideyuki Suzuki; Iwao Sasaki; Ken ichi Takahashi; Yuji Funayama

doi:10.5833/jjgs.43.270

Clostridium difficile-associated refractory pouchitis: Report of three cases

Hitoshi Ogawa, Kouhei Fukushima, Chikashi Shibata, Koh Miura, Sho Haneda, Keiichi Hayashi, Hideyuki Suzuki, Iwao Sasaki, Ken ichi Takahashi, Yuji Funayama

Research output: Contribution to journal › Article

Abstract

Pouchitis-the most common complication of total proctocolectomy and anal ileal-pouch anastomosis for ulcerative colitis-is effectively treated in most patients by antibiotic ciprofloxacin or metronidazole therapy, In some cases, however, pouchitis is refractory to these antibiotics. We detected Clostridium difficile toxin A in the feces of three patients suffering from antibiotic-refractory pouchitis whose mucosal inflammation was ameliorated by oral vancomycin treatment. C. difficile should therefore be considered in antibiotic-refractory pouchitis, which requires appropriate medication.

Original language	English
Pages (from-to)	270-276
Number of pages	7
Journal	Japanese Journal of Gastroenterological Surgery
Volume	43
Issue number	3
DOIs	https://doi.org/10.5833/jjgs.43.270
Publication status	Published - 2010 Mar

Keywords

C. Difficile
Pouchitis

ASJC Scopus subject areas

Surgery
Gastroenterology

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Ogawa, H., Fukushima, K., Shibata, C., Miura, K., Haneda, S., Hayashi, K., Suzuki, H., Sasaki, I., Takahashi, K. I., & Funayama, Y. (2010). Clostridium difficile-associated refractory pouchitis: Report of three cases. Japanese Journal of Gastroenterological Surgery, 43(3), 270-276. https://doi.org/10.5833/jjgs.43.270

Clostridium difficile-associated refractory pouchitis : Report of three cases. / Ogawa, Hitoshi; Fukushima, Kouhei; Shibata, Chikashi; Miura, Koh; Haneda, Sho; Hayashi, Keiichi; Suzuki, Hideyuki; Sasaki, Iwao; Takahashi, Ken ichi; Funayama, Yuji.

In: Japanese Journal of Gastroenterological Surgery, Vol. 43, No. 3, 03.2010, p. 270-276.

Research output: Contribution to journal › Article

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