Clostridium difficile-associated refractory pouchitis: Report of three cases

Hitoshi Ogawa, Kouhei Fukushima, Chikashi Shibata, Koh Miura, Sho Haneda, Keiichi Hayashi, Hideyuki Suzuki, Iwao Sasaki, Ken ichi Takahashi, Yuji Funayama

Research output: Contribution to journalArticle

Abstract

Pouchitis-the most common complication of total proctocolectomy and anal ileal-pouch anastomosis for ulcerative colitis-is effectively treated in most patients by antibiotic ciprofloxacin or metronidazole therapy, In some cases, however, pouchitis is refractory to these antibiotics. We detected Clostridium difficile toxin A in the feces of three patients suffering from antibiotic-refractory pouchitis whose mucosal inflammation was ameliorated by oral vancomycin treatment. C. difficile should therefore be considered in antibiotic-refractory pouchitis, which requires appropriate medication.

Original languageEnglish
Pages (from-to)270-276
Number of pages7
JournalJapanese Journal of Gastroenterological Surgery
Volume43
Issue number3
DOIs
Publication statusPublished - 2010 Mar

Keywords

  • C. Difficile
  • Pouchitis

ASJC Scopus subject areas

  • Surgery
  • Gastroenterology

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    Ogawa, H., Fukushima, K., Shibata, C., Miura, K., Haneda, S., Hayashi, K., Suzuki, H., Sasaki, I., Takahashi, K. I., & Funayama, Y. (2010). Clostridium difficile-associated refractory pouchitis: Report of three cases. Japanese Journal of Gastroenterological Surgery, 43(3), 270-276. https://doi.org/10.5833/jjgs.43.270