Close linkage of human chromosomal pepsinogen A genes

Toshiya Hayano, Kazuhiro Sogawa, Yoshikazu Ichihara, Yoshiaki Fujii-Kuriyama, Kenji Takahashi

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

We have obtained a clone containing two pepsinogen A genes in a single insert by screening a recombinant cosmid library for human genomic DNA. Restriction endonuclease mappings of this cloned DNA showed that these two genes are very similar, but distinct in structure, and that they are closely linked to one another in the human chromosome DNA. The close arrangement of the genes with very similar structures could facilitate the homologous recombination or the unequal crossing-over which accounts for high frequency of haplotype variation in copy number of pepsinogen A genes as reported by Taggart et al.

Original languageEnglish
Pages (from-to)289-296
Number of pages8
JournalBiochemical and biophysical research communications
Volume138
Issue number1
DOIs
Publication statusPublished - 1986 Jul 16
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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