Close linkage between calcium/calmodulin kinase II α/β and NMDA-2A receptors in the lateral amygdala and significance for retrieval of auditory fear conditioning

Takahiro Moriya, Yasuko Kouzu, Shigenobu Shibata, Hiroshi Kadotani, Koji Fukunaga, Eishichi Miyamoto, Tohru Yoshioka

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)

Abstract

The general mechanism underlying memory and learning is an area under intense investigation and debate, yet this mechanism remains elusive. Auditory fear conditioning (when a tone is paired with a foot shock) is a simple associative form of learning for which many mechanistic details are known. Lesions of the lateral/basolateral nuclei of the amygdala result in the selective impairment of fear conditioning, indicating that this is a key region for this type of learning. Fear conditioning induces a lasting synaptic potentiation in the lateral nuclei of the amygdala. In addition, recent results from several laboratories suggest that N-methyl-D-aspartate (NMDA) receptor activation in the amygdala is required for the acquisition and expression of cue-conditioned fear responses using several kinds of antagonists. Little is known, however, about the signal transduction pathway and molecular substrate underlying fear conditioning. Here we use NMDA receptor-deficient mice to demonstrate that calmodulin-dependent kinase II, CaMKIIβ, and CaMKIIα activation involves the NR2A subunit in the lateral/basolateral amygdala during memory retrieval following auditory fear conditioning. These results suggest that auditory fear conditioning involves a close linkage between NMDA2A receptors and the CaMKII cascade.

Original languageEnglish
Pages (from-to)3307-3314
Number of pages8
JournalEuropean Journal of Neuroscience
Volume12
Issue number9
DOIs
Publication statusPublished - 2000 Oct 17

Keywords

  • Associated learning
  • CaMKII
  • Glutamate
  • Mutant mice

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint

Dive into the research topics of 'Close linkage between calcium/calmodulin kinase II α/β and NMDA-2A receptors in the lateral amygdala and significance for retrieval of auditory fear conditioning'. Together they form a unique fingerprint.

Cite this