Close encounters with apolipoprotein E receptors

Tokuo Yamamoto, Hideaki Bujo

Research output: Contribution to journalShort surveypeer-review

26 Citations (Scopus)

Abstract

Most of the LDL receptor family members recognize apolipoprotein E. The structures of the VLDL receptor, and recently identified apolipoprotein E receptor 2, closely resemble the LDL receptor. Recent studies have demonstrated that the VLDL receptor is responsible for the reproduction of premammalian species by mediating oogenesis. Despite the importance of the VLDL receptor in premammalian species, the biological role of the mammalian VLDL receptor is still unclear. Apolipoprotein E receptor 2 is structurally most closely related to the LDL receptor and expressed predominantly in brain. This newly identified receptor may play a role in the uptake of cholesterol in the central nervous system.

Original languageEnglish
Pages (from-to)298-302
Number of pages5
JournalCurrent Opinion in Lipidology
Volume7
Issue number5
DOIs
Publication statusPublished - 1996 Jan 1

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Molecular Biology
  • Genetics
  • Nutrition and Dietetics
  • Cardiology and Cardiovascular Medicine
  • Cell Biology

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