Cloning of 67-kDa laminin receptor cDNA and gene expression in normal and malignant cell lines of the human lung

Ken Satoh, Koh Narumi, Toshihiko Sakai, Tatsuya Abe, Toshiaki Kikuchi, Keiko Matsushima, Satoshi Sindoh, Masakichi Motomiya

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

Cell-adhesive protein laminin and its specific receptor play an important role in the processes of cancer proliferation, invasion and metastasis. In the present study, we cloned the cDNAs of the 67-kDa laminin receptor both from a human lung cell line (IMR90) and from a human lung cancer cell line (SBC3), and determined the nucleotide sequences. In comparison with both cDNA sequences of the protein-coding region, three nucleotide differences were found. These differences in the secondary structure of the protein, however, were caused by nucleotide substitutions. It was also demonstrated that the level of 67-kDa-laminin receptor mRNA was higher in SBC3 than in IMR90.

Original languageEnglish
Pages (from-to)199-203
Number of pages5
JournalCancer Letters
Volume62
Issue number3
DOIs
Publication statusPublished - 1992 Mar 15

Keywords

  • cDNA
  • human
  • laminin
  • lung cancer
  • receptor

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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