Cloning, mapping and expression of PEBP2αC, a third gene encoding the mammalian Runt domain

Suk Chul Bae, Ei ichi Takahashi, Yu Wen Zhang, Eiko Ogawa, Katsuya Shigesada, Yuziro Namba, Masanobu Satake, Yoshiaki Ito

Research output: Contribution to journalArticlepeer-review

151 Citations (Scopus)

Abstract

PEBP2/CBF is a heterodimeric transcription factor composed of α and β subunits. Previously, we reported two distinct mouse genes, PEBP2αA and PEBP2αB, which encode the α subunit. PEBP2αB is the homologue of human AML1, encoding the acute myeloid leukemia 1 protein. AMLI and human PEBP2/CBFβ were detected independently at the breakpoints of two characteristic chromosome translocations observed frequently in two subtypes of acute myeloid leukemia. The PEBP2α proteins contain a 128-amino-acid (aa) region highly homologous to the Drosophila melanogaster segmentation gene runt. The evolutionarily conserved region, named the Runt domain, harbors DNA-binding and heterodimerizing activities. In this study, we identified the third Runt-domain-encoding gene, PEBP2αC, which maps to lp36.11-p36.13 in the human chromosome and encodes a 415-aa protein. PEBP2αC forms a heterodimer with PEBP2β, binds to the PEBP2 site and transactivates transcription, similar to PEBP2αA and PEBP2αB.

Original languageEnglish
Pages (from-to)245-248
Number of pages4
JournalGene
Volume159
Issue number2
DOIs
Publication statusPublished - 1995

Keywords

  • AML1
  • Human cDNA
  • chromosome translocation
  • transcription factor

ASJC Scopus subject areas

  • Genetics

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