Cloning and structure-function analyses of quinolone- and acridone-producing novel type III polyketide synthases from citrus microcarpa

Takahiro Mori, Yoshihiko Shimokawa, Takashi Matsui, Keishi Kinjo, Ryohei Kato, Hiroshi Noguchi, Shigetoshi Sugio, Hiroyuki Morita, Ikuro Abe

    Research output: Contribution to journalArticlepeer-review

    20 Citations (Scopus)

    Abstract

    Background:Type III polyketide synthases (PKSs) synthesize various polyketide and alkaloid scaffolds. Results:QNS synthesizes quinolone as the single product, whereas ACS produces acridone as the major product. Conclusion:QNS and ACS are novel quinolone- and acridone-producing type III PKSs, respectively. Significance:Structure-function analyses of QNS and ACS provide insights into molecular bases for alkaloid biosyntheses.

    Original languageEnglish
    Pages (from-to)28845-28858
    Number of pages14
    JournalJournal of Biological Chemistry
    Volume288
    Issue number40
    DOIs
    Publication statusPublished - 2013 Oct 4

    ASJC Scopus subject areas

    • Biochemistry
    • Molecular Biology
    • Cell Biology

    Fingerprint

    Dive into the research topics of 'Cloning and structure-function analyses of quinolone- and acridone-producing novel type III polyketide synthases from citrus microcarpa'. Together they form a unique fingerprint.

    Cite this