Cloning and structure-function analyses of quinolone- and acridone-producing novel type III polyketide synthases from citrus microcarpa

Takahiro Mori, Yoshihiko Shimokawa, Takashi Matsui, Keishi Kinjo, Ryohei Kato, Hiroshi Noguchi, Shigetoshi Sugio, Hiroyuki Morita, Ikuro Abe

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

Background:Type III polyketide synthases (PKSs) synthesize various polyketide and alkaloid scaffolds. Results:QNS synthesizes quinolone as the single product, whereas ACS produces acridone as the major product. Conclusion:QNS and ACS are novel quinolone- and acridone-producing type III PKSs, respectively. Significance:Structure-function analyses of QNS and ACS provide insights into molecular bases for alkaloid biosyntheses.

Original languageEnglish
Pages (from-to)28845-28858
Number of pages14
JournalJournal of Biological Chemistry
Volume288
Issue number40
DOIs
Publication statusPublished - 2013 Oct 4
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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