Abstract
DNA complementary to the rat hypothalamic mRNA coding for the corticotropin-releasing factor precursor (prepro-CRF) has been cloned by screening a cDNA library with a human genomic DNA probe. Nucleotide sequence analysis of the cloned cDNA has revealed that rat prepro-CRF consists of 187 amino acid residues including a putative signal peptide. The CRF and putative signal peptide regions are more highly conserved among rat, human and ovine prepro-CRF than is the cryptic portion.
Original language | English |
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Pages (from-to) | 63-66 |
Number of pages | 4 |
Journal | FEBS Letters |
Volume | 191 |
Issue number | 1 |
DOIs | |
Publication status | Published - 1985 Oct 21 |
Keywords
- Corticotropin-releasing factor
- Hormone precursor
- Nucleotide sequence
- cDNA cloning
ASJC Scopus subject areas
- Biophysics
- Structural Biology
- Biochemistry
- Molecular Biology
- Genetics
- Cell Biology