Clonal identification of Burkitt's lymphoma arising from lymphocyte-predominant Hodgkin's disease

Haruhiko Yoshinaga, Kazuteru Ohashi, Koh Yamamoto, Tohru Miki, Osamu Miura, Takako Saito, Takatoshi Koyama, Akira Kanazawa, Tetsuo Nemoto, Nobuyuki Miyasaka, Ryuichi Kamiyama, Shinsaku Hirosawa

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

The occurrence of large cell lymphomas subsequent to, or concurrent with, lymphocyte predominant Hodgkin's disease (LPHD) is a well-documented phenomenon. We present a case of Burkitt's lymphoma of the bladder, occurring after the successful treatment of LPHD of a cervical lymph node. To evaluate the clonal relationship of the two tumours, we amplified the complementarity-determining-region 3 of two samples from paraffin-embedded slides, using the polymerase chain reaction (PCR). The sequences of the PCR products showed 96% homology to each other. These results indicate that the malignant clone of Burkitt's lymphoma arose from the corresponding LPHD.

Original languageEnglish
Pages (from-to)380-382
Number of pages3
JournalBritish Journal of Haematology
Volume95
Issue number2
DOIs
Publication statusPublished - 1996 Jan 1
Externally publishedYes

Keywords

  • Burkitt's lymphoma
  • Clonality
  • Hodgkin's disease
  • Polymerase chain reaction

ASJC Scopus subject areas

  • Hematology

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