Clock gene expression in the submandibular glands

M. Furukawa, T. Kawamoto, M. Noshiro, K. K. Honda, M. Sakai, K. Fujimoto, S. Honma, K. Honma, T. Hamada, Y. Kato

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)


Clock genes, which mediate molecular circadian rhythms, are expressed in a circadian fashion in the suprachiasmatic nucleus and in various peripheral tissues. To establish a molecular basis for circadian regulation in the salivary glands, we examined expression profiles of clock-related genes and salivary gland-characteristic genes. Clock-related genes-including Per1, Per2, Cry1, Bmal1, Dec1, Dec2, Dbp, and Rev-erbα-showed robust circadian expression rhythms in the submandibular glands in 12:12-hour light-dark conditions. In addition, a robust circadian rhythm was observed in amylase 1 mRNA levels, whereas the expression of other salivary-gland-characteristic genes examined was not rhythmic. The Clock mutation resulted in increased or decreased mRNA levels of Per2, Bmal1, Dec1, Dec2, and Dbp, and in Cry1-/- background, Cry2 disruption also increased or decreased mRNA levels of these clock-related genes and the amylase 1 gene. These findings indicate that the Clock- and Cry-dependent molecular clock system is active in the salivary glands.

Original languageEnglish
Pages (from-to)1193-1197
Number of pages5
JournalJournal of dental research
Issue number12
Publication statusPublished - 2005 Dec


  • Amylase
  • Circadian rhythm
  • Clock
  • Dec.
  • Salivary gland

ASJC Scopus subject areas

  • Dentistry(all)


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