Clinicopathological features of lipomas with gene fusions involving HMGA2

Hiroshi Hatano, Tetsuro Morita, Akira Ogose, Tetsuo Hotta, Hiroto Kobayashi, Hiroyuki Segawa, Toru Uchiyama, Tatsuya Takenouchi, Toyoji Sato

    Research output: Contribution to journalArticlepeer-review

    10 Citations (Scopus)

    Abstract

    Background: Despite accumulating knowledge of chimeric genes derived from fusion of the HMGA2 gene with multiple partners in lipomas, the different clinicopathological features of lipomas depending on different gene aberrations have not been well documented. The purpose of this study was to examine the clinical significance of the expression of fusion genes in lipomas. Patients and Methods: The expressions of three previously reported gene fusion transcripts, including HMGA2/LPP, HMGA2/RDC1 and HMGA2/NFIB, were analyzed in 102 tumors from patients with lipomas. Results: There were 23 cases (22.5%) expressing HMGA2/LPP, 2 cases (1.9%) expressing HMGA2/RDC1 and no cases of HMGA2/NFIB expression (0%). There were no significant intergroup differences in age, gender, body mass index, tumor size or location. The magnetic resonance images and pathological features were also not different in regard to the status affusion gene expression. Conclusion: There were no significant differences of clinicopathological features in patients with lipoma with or without these fusion gene transcripts.

    Original languageEnglish
    Pages (from-to)535-538
    Number of pages4
    JournalAnticancer Research
    Volume28
    Issue number1 B
    Publication statusPublished - 2008 Jan

    Keywords

    • Fusion genes
    • HMGA2
    • Lipoma

    ASJC Scopus subject areas

    • Cancer Research
    • Oncology

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