Clinicopathologic significance of immunostaining of α-thalassemia/ mental retardation syndrome X-linked protein and death domain-associated protein in neuroendocrine tumors

Shi Fan Chen, Atsuko Kasajima, Samaneh Yazdani, Monica S.M. Chan, Lin Wang, Yang Yang He, Hong Wen Gao, Hironobu Sasano

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

Summary α-Thalassemia/mental retardation syndrome X-linked protein (ATRX) and death domain-associated protein (DAXX) genes are tumor suppressors whose mutations have been identified in sporadic pancreatic neuroendocrine tumors as well as in patients with MEN1. However, it is unknown whether ATRX and DAXX alterations are specific for pancreatic neuroendocrine tumor. In addition, the association of ATRX/DAXX protein loss with tumor cell proliferation has not been examined. We, therefore, immunostained ATRX and DAXX in 10 gastric, 15 duodenal, 20 rectal, 70 pancreatic, and 22 pulmonary neuroendocrine tumors with 15 nonneoplastic pancreases and 27 pancreatic adenocarcinomas to elucidate the site-specific roles of ATRX/DAXX abnormalities. At least 1 loss of ATRX and DAXX immunoreactivity was detected in all neuroendocrine tumor cases but not in any of nonneoplastic pancreatic tissues or pancreatic adenocarcinomas. The loss of DAXX protein was correlated with the Ki-67 index (ATRX, P =.904; DAXX, P =.044). The status of DAXX immunoreactivity correlated positively with World Health Organization histologic grade (P =.026). These results suggest that the status of ATRX or DAXX protein loss in neuroendocrine tumor differed among the organs in which these tumors arose, and these proteins may play site-specific roles in the development of these tumors.

Original languageEnglish
Pages (from-to)2199-2203
Number of pages5
JournalHuman Pathology
Volume44
Issue number10
DOIs
Publication statusPublished - 2013 Oct

Keywords

  • ATRX
  • DAXX
  • Neuroendocrine tumors

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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