Clinical validity of the Japanese version of the Functional Assessment of Cancer Therapy-Anemia Scale

Maya Kurita, Kojiro Shimozuma, Satoshi Morita, Yuki Fujiki, Kenichi Ishizawa, Hisae Eguchi, Yuko Saito, Nobuko Ushirozawa, Izumi Wasada, Yasuo Ohashi, Kenji Eguchi

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    Abstract

    Goals of work: The purpose of this study was to reveal the clinical validity of the Japanese version of the Functional Assessment of Cancer Therapy-Anemia scale (FACT-An) in relation to hemoglobin level. We also analyzed patients' scores for the related FACT-General scale (FACT-G), the FACT Anemia subscale, and the FACT Trial Outcome Index-Anemia scale (FACT TOI-An) to determine which was the most sensitive to anemia measurements. Materials and methods: Throughout Japan, we recruited 227 patients (mean±SD, 59±12.1 years old) diagnosed with a variety of cancers. We correlated the severity of anemia, as measured by hemoglobin levels, to scores on the FACT-An and on the other scales at baseline and at 3 months. Main results: The questionnaire completion rate was more than 98% at both time points. The FACT-An had high internal consistency (Cronbach's alpha coefficient >0.8). FACT-An scores were significantly and positively correlated with hemoglobin levels both at baseline (r=0.24; 95% CI=0.12 to 0.36; n=225) and at 3 months (r=0.24; 95% CI=0.10 to 0.36; n=204). FACT-G, FACT Anemia subscale, and FACT TOI-An scores also successfully discriminated between patients with lower (Hb <11.0 g/dl) and higher (Hb ≥11.0 g/dl) hemoglobin levels. Moreover, the changes of these FACT scores over 3-months could discriminate changes in hemoglobin level. Conclusion: The Japanese version of the FACT-An has higher clinical validity and can be used to appropriately assess health-related quality of life among Japanese cancer patients with anemia.

    Original languageEnglish
    Pages (from-to)1-6
    Number of pages6
    JournalSupportive Care in Cancer
    Volume15
    Issue number1
    DOIs
    Publication statusPublished - 2007 Jan 1

    Keywords

    • Anemia
    • Cancer
    • Functional Assessment of Cancer Therapy
    • Quality of life
    • Validity

    ASJC Scopus subject areas

    • Oncology

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  • Cite this

    Kurita, M., Shimozuma, K., Morita, S., Fujiki, Y., Ishizawa, K., Eguchi, H., Saito, Y., Ushirozawa, N., Wasada, I., Ohashi, Y., & Eguchi, K. (2007). Clinical validity of the Japanese version of the Functional Assessment of Cancer Therapy-Anemia Scale. Supportive Care in Cancer, 15(1), 1-6. https://doi.org/10.1007/s00520-006-0138-2