Clinical utility of apparent diffusion coefficient and diffusion-weighted magnetic resonance imaging for resectability assessment of head and neck tumors with skull base invasion

Takenori Ogawa, Ikuho Kojima, Shun Wakamori, Takuya Yoshida, Takaki Murata, Maya Sakamoto, Akira Ohkoshi, Ayako Nakanome, Hidenori Endo, Toshiki Endo, Hajime Usubuchi, Yukio Katori

Research output: Contribution to journalArticle

Abstract

Background: The usefulness of apparent diffusion coefficient (ADC) and diffusion-weighted magnetic resonance imaging (DWI) in the detection of malignant tumors has been reported. The purpose of this study is to clarify the role of ADC and DWI for diagnosis of skull base tumors. Methods: A total of 27 patients with head and neck tumors with skull base invasions undergoing skull base surgery were enrolled in this study. Pathological findings of dural invasion and bone invasion were compared with the diagnostic imaging. Results: Advanced magnetic resonance imaging techniques revealed that ADC values in regions of pathological bone and dural invasions were significantly lower than in regions of no invasion. The area under the curve of ADC in bone invasions and dural invasions were 0.957 and 0.894, respectively. Conclusions: Our findings indicate that ADC and DWI are useful tools for the diagnosis of head and neck tumors with skull base invasion.

Original languageEnglish
Pages (from-to)2896-2904
Number of pages9
JournalHead and Neck
Volume42
Issue number10
DOIs
Publication statusAccepted/In press - 2020

Keywords

  • ADC
  • DWI
  • MRI
  • head and neck cancer
  • skull base tumor

ASJC Scopus subject areas

  • Otorhinolaryngology

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