Clinical Usefulness of 11C-MET PET and 201Tl SPECT for Differentiation of Recurrent Glioma from Radiation Necrosis

Yukihiko Sonoda, Toshihiro Kumabe, Toshiei Takahashi, Reizo Shirane, Takashi Yoshimoto

    Research output: Contribution to journalArticlepeer-review

    83 Citations (Scopus)

    Abstract

    The clinical usefulness of L-methyl-11C-methionine positron emission tomography (11C-MET PET) and thallium-201 single photon emission computed tomography (201Tl SPECT) for distinguishing glioma recurrence from radiation-induced changes was evaluated. Ten patients with lesions highly suggestive of recurrent glioma on magnetic resonance imaging underwent 11C-MET PET and 201Tl SPECT studies. Two patients were examined twice, so a total of 12 studies were performed. The clinical diagnoses were five recurrent gliomas and seven radiation necrosis. The five recurrent gliomas appeared as increased uptakes on both 11C-MET PET and 201Tl SPECT scans. Four of the seven radiation necrosis lesions also appeared as increased uptakes on the 201Tl SPECT scans. In contrast, only one radiation necrosis appeared as increased uptake on the 11C-MET PET scans. There was no significant difference in 201Tl SPECT indices between radiation necrosis and tumor recurrence, but the ratio of the differential absorption ratio of tumor tissue to that of the homologous contralateral gray matter in PET of recurrent glioma was significantly higher than that of radiation necrosis. 11C-MET PET is superior to 201Tl SPECT for the differentiation of tumor recurrence from radiation necrosis and delineation of the extent of the tumor.

    Original languageEnglish
    Pages (from-to)342-348
    Number of pages7
    JournalNeurologia medico-chirurgica
    Volume38
    Issue number6
    DOIs
    Publication statusPublished - 1998

    Keywords

    • L-methyl-C-methionine
    • positron emission tomography
    • radiation necrosis
    • recurrent glioma
    • single photon emission computed tomography
    • thallium-201

    ASJC Scopus subject areas

    • Surgery
    • Clinical Neurology

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