Clinical study of miconazole in deep-seated mycoses with evaluation of serological diagnosis

Shigeru Kohno; Kohtaro Mitsutake; Tetsuhiro Noda; Haruko Matsuda; Shigefumi Maesaki; Akira Yasuoka; Mitsuo Kaku; Hironobu Koga; Kohei Hara; Iwamoto Masanori; Inoue Yuichi; Toru Ishino; Kiyo Fujita; Masao Nakatomi; Osamu Sakito; Naomi Ito; Kazuo Sasayama; Masamoto Nakano; Kenji Irifune; Koichi Watanabe; Takeshi Ishizaki; Makiko Seto; Genichiro Mameya; Kenichi Tanaka; Touru Fujino; Hiroshi Yamada; Hideo Mashimoto; Naofumi Suyama; Jun Araki; Sadahiro Asai; Tatsuya Katsumata; Rokushi Oka; Akira Sakamoto; Takashige Miyazaki; Kiyoyasu Fukuhima; Kazuhiro Okuno; Masahiro Yatsugi; Miyako Ishiguro; Tetsuro Kanda; Toshiyuki Oe

doi:10.11250/chemotherapy1953.40.638

Clinical study of miconazole in deep-seated mycoses with evaluation of serological diagnosis

Shigeru Kohno, Kohtaro Mitsutake, Tetsuhiro Noda, Haruko Matsuda, Shigefumi Maesaki, Akira Yasuoka, Mitsuo Kaku, Hironobu Koga, Kohei Hara, Iwamoto Masanori, Inoue Yuichi, Toru Ishino, Kiyo Fujita, Masao Nakatomi, Osamu Sakito, Naomi Ito, Kazuo Sasayama, Masamoto Nakano, Kenji Irifune, Koichi WatanabeTakeshi Ishizaki, Makiko Seto, Genichiro Mameya, Kenichi Tanaka, Touru Fujino, Hiroshi Yamada, Hideo Mashimoto, Naofumi Suyama, Jun Araki, Sadahiro Asai, Tatsuya Katsumata, Rokushi Oka, Akira Sakamoto, Takashige Miyazaki, Kiyoyasu Fukuhima, Kazuhiro Okuno, Masahiro Yatsugi, Miyako Ishiguro, Tetsuro Kanda, Toshiyuki Oe

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Sixty three cases of deep-seated mycosis, mainly complications of diseases of the central nervous system or lung, were treated with daily doses of 800–1,200 mg of miconazole for 20.1 ±12.2 days. Mycological eradication rates were 50% (9 of 18) for confirmed cases of deep-seated mycosis, and 66.7% (6 of 9) for candidemia. Clinical response rates were 61.9% (13 of 21) for confirmed cases of deep-seated mycosis and 90% (9 of 10) for candidemia. Side effects, including abdominal symptoms in 10 cases, of miconazole were observed in 11 of 63 cases (17.5%). Abnormal laboratory data, such as liver dysfunction in 3 cases, were observed in 6 of 63 cases (9.5%). Sero-diagnostic methods for deep-seated mycoses were studied. To measure the fungal index mean beta-glucan, we used the endotoxin test D minus endospecy, with positive results of greater than 60 pg/ml in 7 of 11 cases (63.6%) of candidemia. Cand-Tec titers of more than 4 × were seen in 7 of 10 cases (70%), and mannnan was positive in 6 of 10 cases (60%). However, a D-arabinitol/creatinine ratio of more than 2.0 was seen in only 2 of 7 cases. In pulmonary aspergillosis, anti-aspergillus antibody was positive in 3 of 4 cases. In pulmonary cryptococcosis, capsular antigen was positive in 3 of 4 cases. These data suggest that a combination of various serodiagnostic methods is useful for diagnosing in deep-seated mycoses.

Original language	English
Pages (from-to)	638-646
Number of pages	9
Journal	Chemotherapy
Volume	40
Issue number	5
DOIs	https://doi.org/10.11250/chemotherapy1953.40.638
Publication status	Published - 1992 May
Externally published	Yes

Keywords

miconazole

ASJC Scopus subject areas

Pharmacology (medical)
Infectious Diseases
Pharmacology
Drug Discovery
Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.11250/chemotherapy1953.40.638

Cite this

Kohno, S., Mitsutake, K., Noda, T., Matsuda, H., Maesaki, S., Yasuoka, A., Kaku, M., Koga, H., Hara, K., Masanori, I., Yuichi, I., Ishino, T., Fujita, K., Nakatomi, M., Sakito, O., Ito, N., Sasayama, K., Nakano, M., Irifune, K., ... Oe, T. (1992). Clinical study of miconazole in deep-seated mycoses with evaluation of serological diagnosis. Chemotherapy, 40(5), 638-646. https://doi.org/10.11250/chemotherapy1953.40.638

Clinical study of miconazole in deep-seated mycoses with evaluation of serological diagnosis. / Kohno, Shigeru; Mitsutake, Kohtaro; Noda, Tetsuhiro; Matsuda, Haruko; Maesaki, Shigefumi; Yasuoka, Akira; Kaku, Mitsuo; Koga, Hironobu; Hara, Kohei; Masanori, Iwamoto; Yuichi, Inoue; Ishino, Toru; Fujita, Kiyo; Nakatomi, Masao; Sakito, Osamu; Ito, Naomi; Sasayama, Kazuo; Nakano, Masamoto; Irifune, Kenji; Watanabe, Koichi; Ishizaki, Takeshi; Seto, Makiko; Mameya, Genichiro; Tanaka, Kenichi; Fujino, Touru; Yamada, Hiroshi; Mashimoto, Hideo; Suyama, Naofumi; Araki, Jun; Asai, Sadahiro; Katsumata, Tatsuya; Oka, Rokushi; Sakamoto, Akira; Miyazaki, Takashige; Fukuhima, Kiyoyasu; Okuno, Kazuhiro; Yatsugi, Masahiro; Ishiguro, Miyako; Kanda, Tetsuro; Oe, Toshiyuki.

In: Chemotherapy, Vol. 40, No. 5, 05.1992, p. 638-646.

Research output: Contribution to journal › Article › peer-review

Kohno, S, Mitsutake, K, Noda, T, Matsuda, H, Maesaki, S, Yasuoka, A, Kaku, M, Koga, H, Hara, K, Masanori, I, Yuichi, I, Ishino, T, Fujita, K, Nakatomi, M, Sakito, O, Ito, N, Sasayama, K, Nakano, M, Irifune, K, Watanabe, K, Ishizaki, T, Seto, M, Mameya, G, Tanaka, K, Fujino, T, Yamada, H, Mashimoto, H, Suyama, N, Araki, J, Asai, S, Katsumata, T, Oka, R, Sakamoto, A, Miyazaki, T, Fukuhima, K, Okuno, K, Yatsugi, M, Ishiguro, M, Kanda, T & Oe, T 1992, 'Clinical study of miconazole in deep-seated mycoses with evaluation of serological diagnosis', Chemotherapy, vol. 40, no. 5, pp. 638-646. https://doi.org/10.11250/chemotherapy1953.40.638

Kohno, Shigeru ; Mitsutake, Kohtaro ; Noda, Tetsuhiro ; Matsuda, Haruko ; Maesaki, Shigefumi ; Yasuoka, Akira ; Kaku, Mitsuo ; Koga, Hironobu ; Hara, Kohei ; Masanori, Iwamoto ; Yuichi, Inoue ; Ishino, Toru ; Fujita, Kiyo ; Nakatomi, Masao ; Sakito, Osamu ; Ito, Naomi ; Sasayama, Kazuo ; Nakano, Masamoto ; Irifune, Kenji ; Watanabe, Koichi ; Ishizaki, Takeshi ; Seto, Makiko ; Mameya, Genichiro ; Tanaka, Kenichi ; Fujino, Touru ; Yamada, Hiroshi ; Mashimoto, Hideo ; Suyama, Naofumi ; Araki, Jun ; Asai, Sadahiro ; Katsumata, Tatsuya ; Oka, Rokushi ; Sakamoto, Akira ; Miyazaki, Takashige ; Fukuhima, Kiyoyasu ; Okuno, Kazuhiro ; Yatsugi, Masahiro ; Ishiguro, Miyako ; Kanda, Tetsuro ; Oe, Toshiyuki. / Clinical study of miconazole in deep-seated mycoses with evaluation of serological diagnosis. In: Chemotherapy. 1992 ; Vol. 40, No. 5. pp. 638-646.

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abstract = "Sixty three cases of deep-seated mycosis, mainly complications of diseases of the central nervous system or lung, were treated with daily doses of 800–1,200 mg of miconazole for 20.1 ±12.2 days. Mycological eradication rates were 50% (9 of 18) for confirmed cases of deep-seated mycosis, and 66.7% (6 of 9) for candidemia. Clinical response rates were 61.9% (13 of 21) for confirmed cases of deep-seated mycosis and 90% (9 of 10) for candidemia. Side effects, including abdominal symptoms in 10 cases, of miconazole were observed in 11 of 63 cases (17.5%). Abnormal laboratory data, such as liver dysfunction in 3 cases, were observed in 6 of 63 cases (9.5%). Sero-diagnostic methods for deep-seated mycoses were studied. To measure the fungal index mean beta-glucan, we used the endotoxin test D minus endospecy, with positive results of greater than 60 pg/ml in 7 of 11 cases (63.6%) of candidemia. Cand-Tec titers of more than 4 × were seen in 7 of 10 cases (70%), and mannnan was positive in 6 of 10 cases (60%). However, a D-arabinitol/creatinine ratio of more than 2.0 was seen in only 2 of 7 cases. In pulmonary aspergillosis, anti-aspergillus antibody was positive in 3 of 4 cases. In pulmonary cryptococcosis, capsular antigen was positive in 3 of 4 cases. These data suggest that a combination of various serodiagnostic methods is useful for diagnosing in deep-seated mycoses.",

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author = "Shigeru Kohno and Kohtaro Mitsutake and Tetsuhiro Noda and Haruko Matsuda and Shigefumi Maesaki and Akira Yasuoka and Mitsuo Kaku and Hironobu Koga and Kohei Hara and Iwamoto Masanori and Inoue Yuichi and Toru Ishino and Kiyo Fujita and Masao Nakatomi and Osamu Sakito and Naomi Ito and Kazuo Sasayama and Masamoto Nakano and Kenji Irifune and Koichi Watanabe and Takeshi Ishizaki and Makiko Seto and Genichiro Mameya and Kenichi Tanaka and Touru Fujino and Hiroshi Yamada and Hideo Mashimoto and Naofumi Suyama and Jun Araki and Sadahiro Asai and Tatsuya Katsumata and Rokushi Oka and Akira Sakamoto and Takashige Miyazaki and Kiyoyasu Fukuhima and Kazuhiro Okuno and Masahiro Yatsugi and Miyako Ishiguro and Tetsuro Kanda and Toshiyuki Oe",

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AU - Matsuda, Haruko

AU - Maesaki, Shigefumi

AU - Yasuoka, Akira

AU - Kaku, Mitsuo

AU - Koga, Hironobu

AU - Hara, Kohei

AU - Masanori, Iwamoto

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AU - Fujita, Kiyo

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AU - Irifune, Kenji

AU - Watanabe, Koichi

AU - Ishizaki, Takeshi

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AU - Mameya, Genichiro

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AU - Mashimoto, Hideo

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AU - Katsumata, Tatsuya

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AU - Miyazaki, Takashige

AU - Fukuhima, Kiyoyasu

AU - Okuno, Kazuhiro

AU - Yatsugi, Masahiro

AU - Ishiguro, Miyako

AU - Kanda, Tetsuro

AU - Oe, Toshiyuki

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N2 - Sixty three cases of deep-seated mycosis, mainly complications of diseases of the central nervous system or lung, were treated with daily doses of 800–1,200 mg of miconazole for 20.1 ±12.2 days. Mycological eradication rates were 50% (9 of 18) for confirmed cases of deep-seated mycosis, and 66.7% (6 of 9) for candidemia. Clinical response rates were 61.9% (13 of 21) for confirmed cases of deep-seated mycosis and 90% (9 of 10) for candidemia. Side effects, including abdominal symptoms in 10 cases, of miconazole were observed in 11 of 63 cases (17.5%). Abnormal laboratory data, such as liver dysfunction in 3 cases, were observed in 6 of 63 cases (9.5%). Sero-diagnostic methods for deep-seated mycoses were studied. To measure the fungal index mean beta-glucan, we used the endotoxin test D minus endospecy, with positive results of greater than 60 pg/ml in 7 of 11 cases (63.6%) of candidemia. Cand-Tec titers of more than 4 × were seen in 7 of 10 cases (70%), and mannnan was positive in 6 of 10 cases (60%). However, a D-arabinitol/creatinine ratio of more than 2.0 was seen in only 2 of 7 cases. In pulmonary aspergillosis, anti-aspergillus antibody was positive in 3 of 4 cases. In pulmonary cryptococcosis, capsular antigen was positive in 3 of 4 cases. These data suggest that a combination of various serodiagnostic methods is useful for diagnosing in deep-seated mycoses.

AB - Sixty three cases of deep-seated mycosis, mainly complications of diseases of the central nervous system or lung, were treated with daily doses of 800–1,200 mg of miconazole for 20.1 ±12.2 days. Mycological eradication rates were 50% (9 of 18) for confirmed cases of deep-seated mycosis, and 66.7% (6 of 9) for candidemia. Clinical response rates were 61.9% (13 of 21) for confirmed cases of deep-seated mycosis and 90% (9 of 10) for candidemia. Side effects, including abdominal symptoms in 10 cases, of miconazole were observed in 11 of 63 cases (17.5%). Abnormal laboratory data, such as liver dysfunction in 3 cases, were observed in 6 of 63 cases (9.5%). Sero-diagnostic methods for deep-seated mycoses were studied. To measure the fungal index mean beta-glucan, we used the endotoxin test D minus endospecy, with positive results of greater than 60 pg/ml in 7 of 11 cases (63.6%) of candidemia. Cand-Tec titers of more than 4 × were seen in 7 of 10 cases (70%), and mannnan was positive in 6 of 10 cases (60%). However, a D-arabinitol/creatinine ratio of more than 2.0 was seen in only 2 of 7 cases. In pulmonary aspergillosis, anti-aspergillus antibody was positive in 3 of 4 cases. In pulmonary cryptococcosis, capsular antigen was positive in 3 of 4 cases. These data suggest that a combination of various serodiagnostic methods is useful for diagnosing in deep-seated mycoses.

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Clinical study of miconazole in deep-seated mycoses with evaluation of serological diagnosis

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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