Clinical significance of glucagon provocation test in the diagnosis of hypergastrinemia

Chiyuki Nakanome, Akira Ishimori, Yoshio Goto, Tadashi Yamazaki, Jinichi Kameyama, Iwao Sasaki, Masaru Inui, Yotaro Furukawa, Kanji Komatsu

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Glucagon provocation test was performed in the patients with hypergastrinemia and hyperchlorhydria to investigate its diagnostic value. A paradoxical response of plasma gastrin level in the patients with the Zollinger-Ellison syndrome and a marked decrease of plasma gastrin level in the patients with gastric ulcer, duodenal ulcer, excluded gastric antrum, multiple endocrine adenomatosis, pernicious anemia and chronic renal failure were demonstrated by glucagon infusion. Glucagon provocation test, therefore, was considered to be of great value in the diagnosis of the Zollinger-Ellison syndrome, particularly, in the case of an excluded gastric antrum in which secretin provocation test caused the false positive result because of a marked increase of pancreatic secretion. Glucagon provocation test in combination with secretin provocation test, therefore, is at present the most preferable diagnostic procedure for detecting the Zollinger-Ellison syndrome.

Original languageEnglish
Pages (from-to)213-222
Number of pages10
JournalGastroenterologia Japonica
Issue number3
Publication statusPublished - 1981 Jun


  • glucagon provocation test
  • multiple endocrine adenomatosis
  • secretin provocation test
  • the ZollingerEllison syndrome
  • the excluded gastric antrum

ASJC Scopus subject areas

  • Gastroenterology


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