TY - JOUR
T1 - Clinical significance of glucagon provocation test in hypergastrinemias
AU - Nakanome, Chiyuki
AU - Goto, Yoshio
AU - Ishimori, Akira
AU - Yamazaki, Tadasbi
AU - Kameyama, Jinichi
AU - Sasaki, Iwao
AU - Inui, Masaru
AU - Furukawa, Yotara
PY - 1981/1/1
Y1 - 1981/1/1
N2 - Glucagon provocation test was performed in the patients with hypergastrinemia and petic ulcer to investigate its diagnostic value. A paradoxical response of plasma gastrin level in the Zollinger-Ellison syndrome was demonstrated by glucagon infusion. Glucagon provocation test, therefore, was considered to be of great value in the differentiation of the Zollinger-Ellison syndrome from other diseases with hypergastrinemia and peptic ulcer. Secretin provocation test sometimes caused the false positive results because of a marked increase of pancreatic secretion. Glucagon provocation test, on the other hand, had less possibility to produce the false positive results because glucagon inhibited the pancreatic secretion. Glucagon provocation test was considered to be more useful than secretin provocation test in this respect. Consequently, glucagon provocation test in combination with secretin provocation test is at present the most preferable diagnostic procedure for detecting the Zollinger-Ellison syndrome.
AB - Glucagon provocation test was performed in the patients with hypergastrinemia and petic ulcer to investigate its diagnostic value. A paradoxical response of plasma gastrin level in the Zollinger-Ellison syndrome was demonstrated by glucagon infusion. Glucagon provocation test, therefore, was considered to be of great value in the differentiation of the Zollinger-Ellison syndrome from other diseases with hypergastrinemia and peptic ulcer. Secretin provocation test sometimes caused the false positive results because of a marked increase of pancreatic secretion. Glucagon provocation test, on the other hand, had less possibility to produce the false positive results because glucagon inhibited the pancreatic secretion. Glucagon provocation test was considered to be more useful than secretin provocation test in this respect. Consequently, glucagon provocation test in combination with secretin provocation test is at present the most preferable diagnostic procedure for detecting the Zollinger-Ellison syndrome.
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U2 - 10.11405/nisshoshi1964.78.822
DO - 10.11405/nisshoshi1964.78.822
M3 - Article
C2 - 7277791
AN - SCOPUS:0019401695
VL - 78
SP - 822
EP - 830
JO - Journal of Japanese Society of Gastroenterology
JF - Journal of Japanese Society of Gastroenterology
SN - 0446-6586
IS - 4
ER -