Clinical significance of c-kit expression in biliary atresia

Abul Faiz Kabir Uddin Ahmed, Masaki Nio, Haruo Ohtani, Hiroshi Nagura, Ryoji Ohi

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

The aim of the present study was to examine the clinical significance of c-kit expression in biliary atresia (BA) using formalin-fixed, paraffin-embedded sections from 21 patients with BA. Patients were divided into group I (n = 8) with good liver function; group II (n = 8) with moderate liver dysfunction; and group III (n = 5) with severe liver dysfunction. Choledochal cysts (CDC, n = 5) and normal liver samples (NL, n = 4) served as controls. The results were analyzed and compared among the groups. Most c-kit+ cells were present in the portal tracts, and their numbers in BA were significantly higher than in the controls (11.12 ± 1.64 vs 2.15 ± 0.15 [mean ± standard error], P = 0.02, BA vs CDC; 11.12 ± 1.64 vs 1.66 ± 0.52, P = 0.03, BA vs NL). Clinical correlation revealed a significantly higher number of c-kit+ cells in group III versus group I (18.10 ± 3.62 vs 8.86 ± 2.51, P = 0.02). These results suggest that c-kit overexpression is associated with an adverse clinical outcome in BA.

Original languageEnglish
Pages (from-to)601-603
Number of pages3
JournalPediatric Surgery International
Volume17
Issue number8
DOIs
Publication statusPublished - 2001

Keywords

  • Biliary atresia
  • C-kit
  • Clinical correlation

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Surgery

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