Clinical remission and histopathological resolution of nodular lesions in a patient with γ3 heavy-chain deposition disease

J. Soma, Y. Tsuchiya, T. Sakuma, Hiroshi Sato

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Heavy-chain deposition disease (HCDD) is a rare entity accompanying to nonamyloidotic monoclonal immunoglobulin deposition disease. We report a case of γ3-HCDD in which follow-up biopsy could be done after complete remission was achieved by chemotherapy. Follow-up biopsy 2 years after initial biopsy showed remarkable diminution of both nodular glomerular lesions and IgG heavy-chain deposits. This is the first case report to indicate that the original structure of glomeruli in patients with HCDD could be restored within a few years by an appropriate treatment at an early stage of the disease.

Original languageEnglish
Pages (from-to)383-387
Number of pages5
JournalClinical Nephrology
Volume69
Issue number5
Publication statusPublished - 2008 May 1

Keywords

  • Chemotherapy
  • Heavy-chain deposition disease
  • Nodular lesion
  • Remission

ASJC Scopus subject areas

  • Nephrology

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