Clinical presentation of Legionella pneumonia: Evaluation of clinical scoring systems and therapeutic efficacy

Naoyuki Miyashita, Futoshi Higa, Yosuke Aoki, Toshiaki Kikuchi, Masafumi Seki, Kazuhiro Tateda, Nobuko Maki, Kazuhiro Uchino, Kazuhiko Ogasawara, Hiroshi Kiyota, Akira Watanabe

    Research output: Contribution to journalArticle

    9 Citations (Scopus)

    Abstract

    To evaluate scoring systems to predict Legionella pneumonia and therapeutic efficacy against Legionella pneumonia, the Japanese Society of Chemotherapy Legionella committee has collected data on cases of Legionella pneumonia from throughout Japan. We analyzed 176 patients with Legionella pneumonia and compared them with 217 patients with Streptococcus pneumoniae pneumonia and 202 patients with Mycoplasma pneumoniae pneumonia. We evaluated four scoring systems, the Winthrop-University Hospital score, Community-Based Pneumonia Incidence Study Group score, and Japan Respiratory Society score, but they demonstrated limited sensitivity and specificity for predicting Legionella pneumonia. Using six clinical and laboratory parameters (high fever, high C-reactive protein, high lactate dehydrogenase, thrombocytopenia, hyponatremia, and unproductive cough) reported by Fiumefreddo and colleagues, only 6% had Legionnella pneumonia when less than 2 parameters were present. The efficacy rates of antibiotics at the time of termination were 94.6% for intravenous antibiotics, including ciprofloxacin and pazufloxacin, and 95.5% for oral antibiotics, including ciprofloxacin, levofloxacin, garenoxacin, moxifloxacin, and clarithromycin. Our results suggested that the previously reported clinical scoring systems to predict Legionnella pneumonia are not useful, but 6 simple diagnostic score accurately ruled out Legionnella pneumonia, which may help to optimize initial empiric therapy. Quinolones and clarithromycin still showed good clinical efficacy against Legionella pneumonia.

    Original languageEnglish
    Pages (from-to)727-732
    Number of pages6
    JournalJournal of Infection and Chemotherapy
    Volume23
    Issue number11
    DOIs
    Publication statusPublished - 2017 Nov

    Keywords

    • Clinical prediction rule
    • Community-acquired pneumonia
    • Legionella
    • Rapid diagnosis
    • Therapeutic efficacy

    ASJC Scopus subject areas

    • Microbiology (medical)
    • Pharmacology (medical)
    • Infectious Diseases

    Fingerprint Dive into the research topics of 'Clinical presentation of Legionella pneumonia: Evaluation of clinical scoring systems and therapeutic efficacy'. Together they form a unique fingerprint.

  • Cite this

    Miyashita, N., Higa, F., Aoki, Y., Kikuchi, T., Seki, M., Tateda, K., Maki, N., Uchino, K., Ogasawara, K., Kiyota, H., & Watanabe, A. (2017). Clinical presentation of Legionella pneumonia: Evaluation of clinical scoring systems and therapeutic efficacy. Journal of Infection and Chemotherapy, 23(11), 727-732. https://doi.org/10.1016/j.jiac.2017.09.001