Clinical practice guidance for next-generation sequencing in cancer diagnosis and treatment (Edition 1.0)

Japanese Society of Medical Oncology, Japan Society of Clinical Oncology, Japanese Cancer Association

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

In Japan, the social (medical) health-care system is on the way to being developed to advance personalized medicine through the implementation of cancer genomic medicine, known as “cancer clinical sequencing,” which uses a next-generation sequencer. However, no Japanese guidance for cancer genomic testing exists. Gene panel testing can be carried out to help determine patient treatment, confirm diagnosis, and evaluate prognostic predictions of patients with mainly solid cancers for whom no standard treatment is available. This guidance describes how to utilize gene panel testing according to the type of cancer: childhood cancer, rare cancer, carcinoma of unknown primary, and other cancers. The level of evidence classification for unified use in Japan is also detailed. This guidance establishes the basic principles of the quality control of specimens, requirements of medical institutions, informed consent, handling of data during the postanalysis stage, and treatment options based on the evidence level. In Japan, gene panel testing for cancer treatment and diagnosis is recommended to comply with this guidance. This is a collaborative work of the Japanese Society of Medical Oncology, Japan Society of Clinical Oncology, and the Japanese Cancer Association.

Original languageEnglish
Pages (from-to)2980-2985
Number of pages6
JournalCancer science
Volume109
Issue number9
DOIs
Publication statusPublished - 2018 Sep

Keywords

  • evidence level
  • gene panel testing
  • guidance
  • next-generation sequencing
  • solid cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Japanese Society of Medical Oncology, Japan Society of Clinical Oncology, & Japanese Cancer Association (2018). Clinical practice guidance for next-generation sequencing in cancer diagnosis and treatment (Edition 1.0). Cancer science, 109(9), 2980-2985. https://doi.org/10.1111/cas.13730