Clinical outcomes of resectable esophageal cancer with supraclavicular lymph node metastases treated with curative intent

Yoshitaka Honma, Nobukazu Hokamura, Kengo Nagashima, Kazuki Sudo, Hirokazu Shoji, Satoru Iwasa, Atsuo Takashima, Ken Kato, Tetsuya Hamaguchi, Narikazu Boku, Rei Umezawa, Yoshinori Ito, Jun Itami, Kazuo Koyanagi, Hiroyasu Igaki, Yuji Tachimori

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: In the seventh edition of the Union for International Cancer Control (UICC) TNM classification, supraclavicular lymph node (SCLN) in regard to thoracic esophageal cancer (EC) is regarded as a distant organ, therefore, if resectable, SCLN metastasis is considered a candidate for systemic chemotherapy. The purpose of this study was to clarify the survival outcome in patients with resectable thoracic EC with SCLN metastases (M1LYM) treated with curative intent. Patients and Methods: Clinical outcomes in patients with resectable thoracic EC with SCLN metastases (M1LYM) treated by esophagectomy or definitive chemoradiotherapy (dCRT) were retrospectively analyzed. Results: A total of 102 patients were divided in three groups: Surgery with perioperative therapy, n=45; surgery alone, n=19; and dCRT, n=38. Overall, median progression-free survival and median survival time were 9.3 and 26.7 months, respectively. The median survival time was 27.5 months in the group treated with surgery with perioperative treatment, 50.6 months in those treated with surgery alone, and 22 months in the dCRT group. No significant survival difference was seen among the three groupS. Conclusion: Over 30% of patients with resectable M1LYM treated with curative intent achieved long-term survival.

Original languageEnglish
Pages (from-to)3741-3749
Number of pages9
JournalAnticancer research
Volume37
Issue number7
DOIs
Publication statusPublished - 2017 Jul
Externally publishedYes

Keywords

  • Chemoradiotherapy
  • Esophageal cancer
  • Supraclavicular lymph node metastases
  • Surgery

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • Cite this

    Honma, Y., Hokamura, N., Nagashima, K., Sudo, K., Shoji, H., Iwasa, S., Takashima, A., Kato, K., Hamaguchi, T., Boku, N., Umezawa, R., Ito, Y., Itami, J., Koyanagi, K., Igaki, H., & Tachimori, Y. (2017). Clinical outcomes of resectable esophageal cancer with supraclavicular lymph node metastases treated with curative intent. Anticancer research, 37(7), 3741-3749. https://doi.org/10.21873/anticanreS.11748