Clinical outcomes of radiotherapy for esophageal cancer between 2004 and 2008: the second survey of the Japanese Radiation Oncology Study Group (JROSG)

Yasumasa Nishimura, Keiichi Jingu, Satoshi Itasaka, Yoshiharu Negoro, Yuji Murakami, Katsuyuki Karasawa, Gen Kawaguchi, Fumiaki Isohashi, Masao Kobayashi, Yoshiyuki Itoh, Takuro Ariga

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10 Citations (Scopus)

Abstract

Background: This second questionnaire-based survey was performed to determine the clinical results of definitive esophageal cancer treatment with radiotherapy (RT) or chemoradiotherapy (CRT) between 2004 and 2008. Materials/methods: Clinical results of definitive RT for patients were collected from major Japanese institutions. Patients were classified into three groups: (A) stage I, (B) resectable stages II–III, (C) unresectable stages III–IVA. For group A, all patients treated with RT alone or CRT were included. For groups B and C, only those treated with CRT were included. Results: In total, 990 patients (group A 259, group B 333, group C 398 patients) were included from 11 institutions. In group A, 199 patients (78 %) were treated with CRT, and 60 patients (23 %) received RT alone. In groups B and C, 420 patients (57 %) were treated with full-dose cisplatin/5-FU, and 181 patients (25 %) with low-dose protracted-infusion cisplatin/5-FU. The median and range of the 5-year overall survival rate were 73 % (40–94 %) for group A, 40 % (0–57 %) for group B, and 18 % (6–26 %) for group C, respectively. The 5-year overall survival rates were consistently good for five high-volume centers where more than 20 patients/year with esophageal cancer were treated definitively as compared with the remaining six medium-volume centers (5–15 patients/year). The median and range of the incidence of grade ≥3 late toxicities were 10 % and 6–22 %, respectively. Conclusions: A wide disparity in 5-year overall survival rates among the institutions was still apparent in the second survey for groups A and B.

Original languageEnglish
Pages (from-to)88-94
Number of pages7
JournalInternational Journal of Clinical Oncology
Volume21
Issue number1
DOIs
Publication statusPublished - 2016 Feb 1

Keywords

  • Chemoradiation therapy
  • Clinical outcome
  • Esophageal cancer
  • National survey

ASJC Scopus subject areas

  • Surgery
  • Hematology
  • Oncology

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