Clinical outcomes and prognostic factors for esophageal cancer in patients aged 80 years or older who were treated with definitive radiotherapy and chemoradiotherapy

Noriyoshi Takahashi, Rei Umezawa, Keita Kishida, Takaya Yamamoto, Yojiro Ishikawa, Kazuya Takeda, Yu Suzuki, Kousei Kawabata, Satoshi Teramura, Keiichi Jingu

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: Aging of populations has been rapidly increasing worldwide. The aim of this study was to identify prognostic factors of overall survival (OS) and progression-free survival (PFS) in patients aged 80 years or older who had esophageal cancer and received radiotherapy. Methods: Patients aged 80 years or older who received radiotherapy between 2004 and 2015 were retrospectively reviewed. Pretreatment age, gender, performance status, Charlson comorbidity index score, tumor location, histology, clinical stage, results of blood tests and treatment methods were obtained to determine prognostic factors of OS and PFS. Survival curves were drawn using the Kaplan–Meier method and prognostic factors were analyzed using Cox’s hazards model. Results: Ninety-two patients were included. Thirty-five patients were treated with chemo-radiotherapy. The median follow-up period was 19.0 months. The 3-year OS and PFS rates were 44.7% and 28.4%, respectively. In multivariate analysis, clinical stage (hazard ratio [HR] 2.28, 95% confidence interval [CI] 1.40–3.73, p = 0.001) and the geriatric nutritional risk index (GNRI, HR 0.95, 95% CI 0.92–0.97, p < 0.001) were significant prognostic factors of OS. Clinical stage (HR 2.06, 95% CI 1.34–3.18, p = 0.001), tumor location (HR 2.04, 95% CI 1.39–3.01, p < 0.001) and GNRI (HR 0.96, 95% CI 0.94–0.99, p = 0.003) were significant prognostic factors of PFS. Conclusion: Clinical stage and GNRI were significant prognostic factors of OS and PFS. Tumor location was a significant prognostic factor of PFS. These prognostic factors might be useful for decision-making for elderly patients with esophageal cancer.

Original languageEnglish
JournalEsophagus
DOIs
Publication statusAccepted/In press - 2021
Externally publishedYes

Keywords

  • Elder
  • Elderly
  • Esophageal cancer
  • Esophagus cancer
  • Radiotherapy

ASJC Scopus subject areas

  • Gastroenterology

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