Clinical outcome of renal artery stenting for hypertension and chronic kidney disease up to 12 months in the J-RAS study: Prospective, single-arm, multicenter clinical study

J-RAS Study Investigators

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Background: Atherosclerotic renal artery stenosis (ARAS) causes renovascular hypertension (HTN) and impairs renal function, leading to chronic kidney disease (CKD). The J-RAS study was a prospective, multicenter study to assess the clinical outcome of renal artery stenting for up to 1 year in Japanese patients with ARAS. Methods and Results: One hundred and forty-nine patients were enrolled between November 2010 and January 2013. The patients were classified into an HTN (n=121) group and a CKD (n=108) group in the primary analysis. The primary efficacy endpoints were change in blood pressure for the HTN group and change in estimated glomerular filtration rate (eGFR) for the CKD group at 1 months. The primary safety endpoint was freedom from major cardiovascular or renal events at 12 months. In the HTN group, the mean systolic blood pressure (SBP) significantly decreased from 161.6±21 mmHg at baseline to 137.0±21 mmHg (P<0.0001). In the CKD group, there was no significant difference in eGFR from 40.7±10 ml · min−1 · 1.73 m−2 at baseline to 40.8±13 ml · min−1 · 1.73 m−2 (P=0.32). The primary safety endpoint was 89.4% at 12 months. Conclusions: In the J-RAS trial, significant SBP reduction was seen in the HTN group, and stabilization of renal function in the CKD group. Renal artery stenting for ARAS is safe and effective in Japanese patients.

Original languageEnglish
Pages (from-to)351-359
Number of pages9
JournalCirculation Journal
Volume79
Issue number2
DOIs
Publication statusPublished - 2015 Jan 16

Keywords

  • Atherosclerotic renal artery stenosis
  • Chronic kidney disease
  • Hypertension
  • Renal artery stenting

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Clinical outcome of renal artery stenting for hypertension and chronic kidney disease up to 12 months in the J-RAS study: Prospective, single-arm, multicenter clinical study'. Together they form a unique fingerprint.

  • Cite this